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首页> 外文期刊>Journal of Nanjing Medical University >Effect of Calcium Intake on Calcium Absorption and Utilization in Rats
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Effect of Calcium Intake on Calcium Absorption and Utilization in Rats

机译：钙摄入对大鼠钙吸收和利用的影响

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Objective: To study the relationship between Ca~(2+) intake, Ca~(2+) absorption and Ca~(2+) retention. Methods; Thirty-six weaning rats were firstly fed with Ca-poor diet for a 3-week Ca~(2+) depletion period, and then randomly divided into 3 groups to receive diet with low, adequate and high Ca~(2+) contents. The experiment lasted 12 weeks, with a 3-day metabolism experiment conducted in the 5th week. Results: Supplement with adequate amount of Ca~(2+) increased bone Ca~(2+), bone mineral density (BMD), bone mineral content (BMC) and the weight of femur (P < 0.05). Higher doses of Ca~(2+) failed to further improve the efficiency. Analysis showed that Ca~(2+) intake was positively correlated to bone Ca~(2+), BND and BMC, and negatively correlated to the rates of Ca~(2+) absorption and retention. Dose-effect study revealed that the Ca~(2+) absorption rate(Y)was a hyperbola function of Ca~(2+) intake(X), i. e. Y = e~(6.8068) x X~(0.8821) + 20(F = 47.3154, P<0.0001). It was found from the results that bone Ca~(2+) content (determined by atom absorption spectropho-tometer)had a linear correlation to BMC (determined with uni-photon bone mineral densitometer). Conclusion: The rate of Ca~(2+) absorption is a hyperbola function of Ca~(2+) intake. The increment of Ca~(2+) absorption will be minimal when Ca~(2+) intake exceeds 3d 250 mg in rats. BMC, better than BMD, may substitute for the ideal bone Ca~(2+) content as the index to assess the efficacy of Ca~(2+) supplement.
机译：目的：研究Ca〜（2+）的摄入，Ca〜（2+）的吸收与Ca〜（2+）的保留之间的关系。方法;首先对36只断奶大鼠进行缺钙饮食，持续3周的Ca〜（2+）消耗，然后随机分为3组，分别接受低，适当和高Ca〜（2+）含量的饮食。实验持续了12周，第5周进行了3天的新陈代谢实验。结果：补充适量的Ca〜（2+）可增加骨骼Ca〜（2+），骨矿物质密度（BMD），骨矿物质含量（BMC）和股骨重量（P <0.05）。高剂量的Ca〜（2+）未能进一步提高效率。分析表明，Ca〜（2+）的摄入量与骨骼中的Ca〜（2 +），BND和BMC呈正相关，而与Ca〜（2+）的吸收和保留率呈负相关。剂量效应研究表明，Ca〜（2+）的吸收率（Y）是Ca〜（2+）摄入量（X）的双曲线函数。 e。 Y = e〜（6.8068）x X〜（0.8821）+ 20（F = 47.3154，P <0.0001）。从结果发现，骨Ca〜（2+）含量（由原子吸收分光光度计测定）与BMC（与单光子骨矿物质密度计测定）呈线性相关。结论：Ca〜（2+）的吸收速率是Ca〜（2+）摄入量的双曲线函数。当大鼠摄入Ca〜（2+）超过3d 250 mg时，Ca〜（2+）的吸收增量将最小。 BMC优于BMD，可以替代理想的骨骼Ca〜（2+）含量作为评估Ca〜（2+）补充剂疗效的指标。

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