The Value of CSF Level of ss- amyloid Protein in the Diagnosis of Alzheimer's Disease

CHENG Hong; DING Xin-sheng; WANG Kun; ZHANG Xue-ling; WANG Ying; YAO Juan; DENG Xiao-xuan

首页> 外文期刊>Journal of Nanjing Medical University >The Value of CSF Level of ss- amyloid Protein in the Diagnosis of Alzheimer's Disease

【24h】

The Value of CSF Level of ss- amyloid Protein in the Diagnosis of Alzheimer's Disease

机译：脑脊液中β-淀粉样蛋白水平在阿尔茨海默氏病诊断中的价值

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Objective: To evaluate the diagnostic potential of cerebrospinal fluid (CSF) levels of β-amyloid protein (Aβ) as biochemical marker for senile dementia in clinical practice. Methods: Sensitive enzyme-linked immunosorbent assay (ELISA) was performed in our laboratory to detect the CSF levels of Aβ_(1-40), Aβ_(1-42) in 54 patients with Alzheimer's disease (AD), and 30 normal controls (NC). Results: The cut off value of Aβ ratio and Aβ_(1-42) concentration in NC group provided 54. 51%, 90. 00% sensitivity and 81. 25%, 84. 38% specificity respectively in diagnosis of AD. Conclusion: AD group had a significant decreased level of Aβ_(1-42) and an increased level of Aβ ratio, compared with NC group.

机译：目的：评价脑脊液中β淀粉样蛋白（Aβ）水平作为老年痴呆症生化指标的诊断潜力。方法：在我们的实验室中进行了敏感的酶联免疫吸附试验（ELISA），以检测54例阿尔茨海默病（AD）患者和30例正常对照的CSF中Aβ_（1-40），Aβ_（1-42）的脑脊液水平。 NC）。结果：NC组Aβ比值和Aβ_（1-42）浓度的临界值分别为AD诊断提供54. 51％，90。00％和81. 25％，84。38％的特异性。结论：与NC组相比，AD组Aβ_（1-42）水平明显降低，Aβ比水平升高。

著录项

来源
《Journal of Nanjing Medical University》 |2003年第3期|p.106-108|共3页
作者
CHENG Hong; DING Xin-sheng; WANG Kun; ZHANG Xue-ling; WANG Ying; YAO Juan; DENG Xiao-xuan;
展开▼
作者单位

Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
alzheimer's disease; cerebrospinal fluid; β-amyloid protein;

机译：阿尔茨海默氏病;脑脊液;β淀粉样蛋白;

相似文献

外文文献
中文文献
专利

1. Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation [J] . John S. K. Kauwe, Matthew H. Bailey, Perry G. Ridge, PLoS Genetics . 2014,第10期

机译：全基因组关联研究59种阿尔茨海默氏病候选蛋白的脑脊液水平：与淀粉样蛋白加工和炎症相关蛋白的显着关联
2. Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation [J] . John S. K. Kauwe, Matthew H. Bailey, Perry G. Ridge, PLoS Genetics . 2014,第10期

机译：全基因组关联研究59种阿尔茨海默氏病候选蛋白的脑脊液水平：与淀粉样蛋白加工和炎症相关蛋白的显着关联
3. CSF p-Tau levels in the prediction of Alzheimer's disease CSF p-Tau levels in the prediction of Alzheimer's disease CSF p-Tau levels in the prediction of Alzheimer's disease [J] . Nidhi Gupta, Willayat Yousuf Wani, Kajal Jain, Biology Open . 2013,第11期

机译：CSF p-Tau水平预测阿尔茨海默氏病CSF p-Tau水平预测阿尔茨海默氏病CSF p-Tau水平预测阿尔茨海默氏病
4. Active site cavities identification of amyloid beta precursor protein: Alzheimer disease study [C] . P. RajaRajeswari, S. Viswanadha Raju, Amira S. Ashour, 20th Jubilee IEEE International Conference on Intelligent Engineering Systems . 2016

机译：淀粉样β前体蛋白的活动部位腔鉴定：阿尔茨海默氏病研究
5. Role of amyloid precursor protein and amyloid-beta in Alzheimer's disease: Modulation of APP processing detection of Abeta oligomers, and their role in the pathogenesis and treatment of AD. [D] . Kim, Minkyu Leo. 2009

机译：淀粉样前体蛋白和淀粉样β在阿尔茨海默氏病中的作用：APP处理Abeta寡聚体检测的调节及其在AD的发病机理和治疗中的作用。
6. Genome-Wide Association Study of CSF Levels of 59 Alzheimers Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation [O] . John S. K. Kauwe, Matthew H. Bailey, Perry G. Ridge, 2014

机译：全基因组关联研究59种阿尔茨海默氏病候选蛋白的脑脊液水平：与淀粉样蛋白加工和炎症相关蛋白的显着关联
7. Genome-wide association study of CSF levels of 59 Alzheimer’s disease candidate proteins: Significant associations with proteins involved in amyloid processing and inflammation [O] . Karch Celeste M, Harari Oscar, Cruchaga Carlos, 2014

机译：全基因组对59种阿尔茨海默氏病候选蛋白CSF水平的关联研究：与淀粉样蛋白加工和炎症相关蛋白的显着关联

The Value of CSF Level of ss- amyloid Protein in the Diagnosis of Alzheimer's Disease

摘要

著录项

相似文献

相关主题

期刊订阅