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首页> 外文期刊>Journal of Nanjing Medical University >The Effects of Apolipoprotein E Polymorphism on Serum Lipids, Lipoproteins and Apolipoproteins Variation
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The Effects of Apolipoprotein E Polymorphism on Serum Lipids, Lipoproteins and Apolipoproteins Variation

机译：载脂蛋白E多态性对血清脂质，脂蛋白和载脂蛋白变异的影响

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Objective: To study the effects of Apolipoprotein E (ApoE) polymorphism on serum levels of lipids, lipoproteins and apolipoproteins. Methods: Fragments of ApoE gene forth ex-on containing codon 112 and 158 polymorphic locus were amplified by PCR, and then digested until Cfo I endonuclease. Genotypes and alleles frequencies of 168 healthy persons in Jiangsu area were calculated. The effects of ApoE genotypes and alleles on serum lipids, lipoproteins and apolipoproteins variation were analyzed. Results: The effects of ApoE alleles on total cholesterol (TC), law density lipoprotein-cholesterol (LDL-C), ApoB was: along a decreasing gradient ε_4>ε_3>ε_2. The effect of ε_4 allele was to increase serum levels of TC, LDL-C and ApoB, and the 臺2 allele had an effect opposite to that of ε_4 allele. Conclusion: ApoE polymorphism is an independent genetic factor on individual serum levels of lipids and apolipoproteins.
机译：目的：研究载脂蛋白E（ApoE）多态性对血清脂质，脂蛋白和载脂蛋白水平的影响。方法：通过PCR扩增含有密码子112和158多态性位点的外显子ApoE基因片段，然后进行酶切直至Cfo I核酸内切酶。计算江苏地区168名健康人的基因型和等位基因频率。分析了ApoE基因型和等位基因对血脂，脂蛋白和载脂蛋白变异的影响。结果：ApoE等位基因对总胆固醇（TC），法密度脂蛋白胆固醇（LDL-C），ApoB的影响为：沿着递减的梯度ε_4>ε_3>ε_2。 ε_4等位基因的作用是增加血清TC，LDL-C和ApoB的水平，而台2等位基因的作用与ε_4等位基因相反。结论：ApoE基因多态性是个体血清脂质和载脂蛋白水平的独立遗传因素。

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