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首页> 外文期刊>Journal of nano research >New Anti-Aging and Anti-Wrinkle Material: Properties and Activities of Nanoparticle Containing Poly(Aspartic Acid) Derivatives
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New Anti-Aging and Anti-Wrinkle Material: Properties and Activities of Nanoparticle Containing Poly(Aspartic Acid) Derivatives

机译：新的抗衰老和抗皱材料：纳米粒子的性质和活性含有聚（天冬氨酸）衍生物

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摘要

Polymers such as sodium polyacrylate; polysaccharides in starch; polyamino acids, which are the products of alpha-amino acid condensation; and polypeptides are widely used in cosmetics and pharmaceuticals. They are used as viscosity agent, emulsifying agent, and carriers for drug delivery. However, we studied the function of polymers as activity agent, especially that of synthesized poly(aspartic acid). Poly(aspartic acid) is a biocompatible synthetic polymer. It is a water-soluble polyamide containing carboxylic pendants prepared from polysuccinimide, the polycondensate of aspartic acid monomer, by hydrolysis. In this study, we prepared poly(aspartic acid) derivatives conjugated with L-lysine or L-lysine and other materials. The chemical structure of these polymers was confirmed by FT-IR and H-1-NMR spectroscopy. Moreover, these novel poly(aspartic acid) derivatives stimulated type I collagen biosynthesis and inhibited MMP-1(collagenase) activity. We could conclude that the microfludization process improved skin permeability and confirmed better permeability than that achieved with existing nano emulsions.
机译：聚合物如聚丙烯酸钠;淀粉中的多糖;聚氨基酸，是α-氨基酸缩合的产物;并且多肽广泛用于化妆品和药物。它们用作药物递送的粘度剂，乳化剂和载体。然而，我们研究了聚合物作为活性剂的功能，特别是合成的聚（天冬氨酸）的功能。聚（天冬氨酸）是生物相容性的合成聚合物。它是一种水溶性聚酰胺，其含有由多琥珀酰亚胺制备的羧末端，通过水解通过水解缩聚物。在这项研究中，我们制备与L-赖氨酸或L-赖氨酸和其他材料缀合的聚（天冬氨酸）衍生物。通过FT-IR和H-1-NMR光谱证实了这些聚合物的化学结构。此外，这些新型聚（天冬氨酸）衍生物刺激I型胶原生物合成，抑制MMP-1（胶原酶）活性。我们可以得出结论，微熔化过程改善了皮肤渗透性，并确认了与现有纳米乳液实现的更好的渗透性。

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