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首页> 外文期刊>Journal of nano research >Reinforcing Mechanical Strength of Electrospun Chitosan Nanofibrous Scaffold Using Cellulose Nanofibers
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Reinforcing Mechanical Strength of Electrospun Chitosan Nanofibrous Scaffold Using Cellulose Nanofibers

机译：使用纤维素纳米纤维增强静电纺丝壳聚糖纳米纤维支架的机械强度

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摘要

In this study, cellulose nanofibers (CNF) was used as a reinforcing material to improve mechanichal strenght of chitosan nanofibrous scaffold. Chitosan scaffolds with different amount of CNF ranging 5.0-20.0 Wt.% were fabricated by adding CNF to chitosan solutions before electrospinning. Both the tensile strength and tensile modulus of the scaffolds were increased as a result of CNF addition. An increase of 4.3 fold (from 2.9±0/02 to 12.7±0/4 MPa) in tensile strength and 4.04 fold (from 86.5±1.7 to 349.5±19.4 P) in Young's modulus were observed after addition of 15 wt. % CNF. The microscopy studies showed that the diameter of the electrospun fibers decreased with the addition of CNF. The diameter decreased from 175± 7 nm to 100±29 nm when 15 wt% CNF were added. Evaluation of cell adhesion by SEM showed that fibroblast cells not only can attachment on the surface of NFC reinforced scaffolds but also can infilterate inside the scaffolds. In addition, the nanocomposite schaffols dose not show any cytotoxic effect using MTT assay.
机译：在这项研究中，纤维素纳米纤维（CNF）被用作增强材料，以提高壳聚糖纳米纤维支架的机械强度。通过在静电纺丝前向壳聚糖溶液中添加CNF来制备具有不同CNF含量范围为5.0-20.0 Wt。％的壳聚糖支架。由于CNF的添加，支架的抗张强度和抗张模量均增加。加入15 wt。％的抗拉强度后，抗张强度增加4.3倍（从2.9±0/02到12.7±0/4 MPa），杨氏模量增加4.04倍（从86.5±1.7到349.5±19.4 P）。 ％CNF。显微镜研究表明，电纺纤维的直径随CNF的增加而减小。当添加15重量％的CNF时，直径从175±7nm减小至100±29nm。通过SEM评估细胞粘附性表明，成纤维细胞不仅可以附着在NFC增强支架的表面上，而且可以渗入支架内部。另外，使用MTT测定法，纳米复合七氢酚没有显示任何细胞毒性作用。

著录项

  • 来源
    《Journal of nano research》 |2018年第2018期|71-79|共9页
  • 作者

    Neda Bohlouli; Esmaeil Mirzaei; Hossein Ghanbari; Seyed Mahdi Rezayat Sorkhabadi; Reza Faridi-Majid;

  • 作者单位

    Department of Medical Nanotechnology, School of Advanced Technologies in Medicine Tehran University of Medical Sciences (TUMS);

    Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies Shiraz University of Medical Sciences;

    Department of Medical Nanotechnology, School of Advanced Technologies in Medicine Tehran University of Medical Sciences (TUMS);

    Department of Medical Nanotechnology, School of Advanced Technologies in Medicine Tehran University of Medical Sciences (TUMS);

    Department of Medical Nanotechnology, School of Advanced Technologies in Medicine Tehran University of Medical Sciences (TUMS);

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Mechanical Strength; Tissue Engineering; Nanocellulose; Chitosan; Nanofibrous Scaffold;

    机译：机械强度;组织工程;纳米纤维素;壳聚糖;纳米纤维支架;

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