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首页> 外文期刊>Journal of nano research >Tin Selenide Quantum Dots Electrochemical Biotransducer for the Determination of Indinavir - A Protease Inhibitor Anti-Retroviral Drug
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Tin Selenide Quantum Dots Electrochemical Biotransducer for the Determination of Indinavir - A Protease Inhibitor Anti-Retroviral Drug

机译：硒化锡量子点电化学生物传感器测定茚地那韦-一种蛋白酶抑制剂抗逆转录病毒药物

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Biocompatibility of tin selenide quantum dots was achieved by the incorporation of 3mercaptopropionic acid (3-MPA) as a capping agent, which also improved the stability and the solubility of the material. The UV-Vis spectrophotometric analysis of the quantum dots revealed a broad absorption band at similar to 330 nm (with a corresponding band gap, Eg, value of 3.75 eV), which is within the range of values expected for quantum dots materials. The 3-mercaptopropionic acid-capped tin selenide (3-MPA-SnSe) quantum dots were used to develop an electrochemical biosensor for indinavir, which is a protease inhibitor antiretroviral (ARV) drug. The biosensor was prepared by the self-assembly of L-cysteine on a gold electrode that was functionalised with (3MPA-SnSe) quantum dots, followed by cross-linking with cytochrome P450-3A4 (CYP3A4) using 1-ethyl-3(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). The electrocatalytic properties of the biosensor included a characteristic cyclic voltammetric reduction peak at - 380 mV, which was used to detect the response of the biosensor to indinavir. The sensor performance parameters included response time and limit of detection (LOD) values of 11 s and 3.22 pg/mL, respectively. The test concentration range studied (0.014 - 0.066 ng/mL) gave a linear calibration plot for indinavir, and it was lower than the physiological plasma concentration index (i. e. maximum plasma concentrations, C-max,) of indinavir (5 - 15 ng/mL) normally observed 8 h after intake. This indicates that the biosensor can be very useful in the case of ultra-rapid metabolisers where very low C-max values are expected
机译：硒化锡量子点的生物相容性通过掺入3巯基丙酸（3-MPA）作为封端剂来实现，这也提高了材料的稳定性和溶解性。量子点的UV-Vis分光光度法分析显示，在类似于330 nm处有较宽的吸收带（相应的带隙Eg，值为3.75 eV），在量子点材料预期的值范围内。 3-巯基丙酸封端的硒化锡（3-MPA-SnSe）量子点用于开发茚地那韦的电化学生物传感器，后者是一种蛋白酶抑制剂抗逆转录病毒（ARV）药物。通过在具有（3MPA-SnSe）量子点功能化的金电极上自组装L-半胱氨酸，然后使用1-乙基-3（3）与细胞色素P450-3A4（CYP3A4）交联来制备生物传感器。 -二甲基氨基丙基）碳二亚胺盐酸盐（EDC）和N-羟基琥珀酰亚胺（NHS）。生物传感器的电催化特性包括一个在-380 mV处的特征性伏安还原峰，用于检测生物传感器对茚地那韦的响应。传感器性能参数包括响应时间和检测极限（LOD）值，分别为11 s和3.22 pg / mL。研究的测试浓度范围（0.014-0.066 ng / mL）给出了茚地那韦的线性校准图，并且低于茚地那韦的生理血浆浓度指数（即最大血浆浓度C-max）（5-15 ng / mL）毫升）通常在摄入后8小时观察到。这表明该生物传感器在预期C-max值非常低的超快速代谢者中非常有用

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