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首页> 外文期刊>Journal of nano research >Reduced Graphene Oxide Paper: Fabrication by a Green Thermal Reduction Method and Preliminary Study of its In Vitro Cytotoxicity
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Reduced Graphene Oxide Paper: Fabrication by a Green Thermal Reduction Method and Preliminary Study of its In Vitro Cytotoxicity

机译：还原氧化石墨烯纸：绿色热还原法制备及其体外细胞毒性的初步研究

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摘要

Graphene films have been intensively explored because of their unique mechanical and physicochemical properties for potential applications in field of tissue engineering and implants. However, for biomedical applications, it is necessary to fully understand the toxicity and biocompatibility of the prepared graphene films since different synthesis method might lead to different biological properties. Here we report a step-by-step thermal reduction method of preparing reduced graphene oxide (rGO) film directly on various substrates at low heating temperature (below about 200 degrees C) without requiring any chemical reduction agent like hydrazine or other reductants (therefore we call it green method). Slowly heating GO hydrosol that was coated on the surface of a glass cell-culture dish or inside of a polypropylene tube from room temperature to 60, 100, and 160 degrees C for 12 h, respectively, a shiny and flat surface without crumpled structure or tiny pores was formed. We peeled it off from the substrate to explore its cytotoxicity. The results exhibited that the rGO film was biocompatible with Cal-72 cell but against Escherichia coli bacteria. Our work confirmed that rGO film produced by the green reduction method is cytocompatible with mammalian cells, which makes this rGO film a promising material for tissue engineering scaffold or as a surface-modification coating of an implant.
机译：由于石墨烯薄膜具有独特的机械和物理化学特性，因此在组织工程和植入物领域的潜在应用受到了广泛的研究。然而，对于生物医学应用，必须充分了解所制备的石墨烯薄膜的毒性和生物相容性，因为不同的合成方法可能导致不同的生物学特性。在这里，我们报告了分步进行的热还原方法，该方法可在较低的加热温度（低于约200摄氏度）下直接在各种基材上制备还原的氧化石墨烯（rGO）膜，而无需使用任何化学还原剂，例如肼或其他还原剂（因此我们称之为绿色方法）。缓慢将涂在玻璃细胞培养皿表面或聚丙烯管内部的GO溶胶从室温分别加热至60、100和160摄氏度，持续12 h，使表面光滑且无皱折的表面或形成了细小的毛孔。我们将其从底物上剥离下来以研究其细胞毒性。结果表明，rGO膜与Cal-72细胞具有生物相容性，但对大肠杆菌具有生物相容性。我们的工作证实，通过绿色还原法生产的rGO膜与哺乳动物细胞具有细胞相容性，这使该rGO膜成为组织工程支架或植入物表面改性涂层的有前途的材料。

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  • 来源
    《Journal of nano research》 |2017年第2017期|199-207|共9页
  • 作者

    Wang Xin; Li Peng; Luedecke Claudia; Zhang Qiang; Wang Zan; Jandt Klaus D.;

  • 作者单位

    Jilin Univ, Coll Mat Sci & Engn, Key Lab Automobile Mat MOE, Changchun 130012, Peoples R China|Friedrich Schiller Univ Jena, Chair Mat Sci, Dept Mat Sci & Technol, Otto Schott Inst Mat Res,Fac Phys & Astron, D-07743 Jena, Germany;

    Jilin Univ, Coll Mat Sci & Engn, Key Lab Automobile Mat MOE, Changchun 130012, Peoples R China;

    Friedrich Schiller Univ Jena, Chair Mat Sci, Dept Mat Sci & Technol, Otto Schott Inst Mat Res,Fac Phys & Astron, D-07743 Jena, Germany;

    Jilin Univ, Coll Mat Sci & Engn, Key Lab Automobile Mat MOE, Changchun 130012, Peoples R China;

    Jilin Univ, Hosp 1, Changchun 130021, Peoples R China;

    Friedrich Schiller Univ Jena, Chair Mat Sci, Dept Mat Sci & Technol, Otto Schott Inst Mat Res,Fac Phys & Astron, D-07743 Jena, Germany|Friedrich Schiller Univ Jena, Jena Ctr Soft Matter, Humboldstr 10, D-07743 Jena, Germany;

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  • 正文语种 eng
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  • 关键词

    Reduced graphene oxide film; Thermal reduction method; Cytotoxicity;

    机译：氧化石墨烯薄膜还原;热还原法;细胞毒性;

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