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首页> 外文期刊>Journal of nano research >Visible Light Triggered Chlorhexidine Release of Nitrogen-Doped TiO2 Nanoparticle Dental Desensitizer
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Visible Light Triggered Chlorhexidine Release of Nitrogen-Doped TiO2 Nanoparticle Dental Desensitizer

机译：氮掺杂的TiO2纳米颗粒牙科脱敏剂的可见光触发氯己定释放

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摘要

The purposes of this study were to develop a novel dental desensitizer with nitrogen-doped TiO2 nanoparticles that show an optical response under visible light and to investigate the triggered release of chlorhexidine from these nanoparticles in response to remote visible-light irradiation. Diffusive ultraviolet-visible spectroscopy indicated that N-doped TiO2 nanoparticles solvothermally treated at 130 degrees C for 2 h showed the highest absorbance at 470 nm. X-ray photoelectron spectroscopy confirmed that nitrogen was substantially doped into the TiO2 lattice via the existence of N-Ti-O or N-Ti-N linkages (396.1 eV of N 1s). Chlorhexidine-release and agar-diffusion antibacterial tests revealed that visible-light irradiation statistically accelerated the release of chlorhexidine, as well as antibacterial activity. An agar overlay biocompatibility test showed that only the 0.1% chlorhexidine experimental group was biocompatible according to ISO 7405. Therefore, N-doped TiO2 nanoparticles should enable the development of new visible-light-mediated antibacterial desensitizers for use in dentistry.
机译：这项研究的目的是开发一种新型的含氮掺杂的TiO2纳米颗粒的牙科脱敏剂，该纳米颗粒在可见光下显示出光学响应，并研究响应于远距离可见光照射而从这些纳米颗粒中触发释放的洗必泰。漫射紫外可见光谱表明，在130℃溶剂热处理2 h的N掺杂的TiO2纳米颗粒在470 nm处显示出最高的吸收率。 X射线光电子能谱证实，通过存在N-Ti-O或N-Ti-N键（N 1s为396.1 eV），氮基本上被掺杂到TiO2晶格中。洗必泰的释放和琼脂扩散抗菌测试表明，可见光辐射在统计学上加速了洗必泰的释放以及抗菌活性。琼脂覆盖物生物相容性测试表明，只有0.1％的洗必泰实验组符合ISO 7405的生物相容性。因此，N掺杂的TiO2纳米颗粒应能够开发用于牙科的新型可见光介导的抗菌脱敏剂。

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