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首页> 外文期刊>Journal of nano research >A Comparison of Magnetometry and Relaxometry Measures of Magnetic Nanoparticles Deposited in Biological Samples
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A Comparison of Magnetometry and Relaxometry Measures of Magnetic Nanoparticles Deposited in Biological Samples

机译：沉积在生物样品中的磁性纳米粒子的磁力测定和弛豫测定方法的比较

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摘要

The Alternating Gradient Field Magnetometer (AGFM) is an instrument whose high sensitivity (10(-8) emu) allows the detection of small amounts of magnetic nanoparticles (MNPs) with high accuracy. Over the last few years, different magnetic techniques have been used for in vitro measurements of magnetic nanostructures inside biological tissues. However, in vivo studies about their distribution within the body are very scarce because their dispersion, after being delivered, reduces their magnetic signal and hinders detection. In this paper we compare the longitudinal relaxation time (T1) and magnetization measurements in mice's biological tissues for the tracking of MNPs after of an injection of iron oxide nanoparticles. Furthermore, we have correlated the AGFM data with Fast Field Cycling NMR Relaxometry (FFCNMR Relaxometry) measurements with histological analysis. The results have demonstrated that these techniques are useful for detecting minute amounts of MNPs in excised organs after comparable to other more conventional techniques for the measurement of MNPs biodistribution and clearance. Details about the preparation of the ex vivo samples, measurement protocol and statistical data processing are given.
机译：交变梯度磁场磁力计（AGFM）是一种仪器，其高灵敏度（10（-8）emu）可以高精度检测少量磁性纳米粒子（MNP）。在过去的几年中，不同的磁性技术已用于体外测量生物组织内部的磁性纳米结构。然而，关于它们在体内的分布的体内研究非常缺乏，因为它们的分散在递送后会降低其磁信号并阻碍检测。在本文中，我们比较了注射氧化铁纳米粒子后小鼠的生物组织中的纵向弛豫时间（T1）和磁化强度测量值，以追踪MNP。此外，我们将AGFM数据与快速场循环NMR弛豫法（FFCNMR弛豫法）测量值与组织学分析相关联。结果表明，与其他更常规的MNPs生物分布和清除率测量技术相比，这些技术可用于检测切除器官中的微量MNPs。给出了有关离体样品制备，测量方案和统计数据处理的详细信息。

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