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首页> 外文期刊>Journal of nano research >Chitosan: Development of Nanoparticles, Other Physical Forms and Solubility with Acids
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Chitosan: Development of Nanoparticles, Other Physical Forms and Solubility with Acids

机译：壳聚糖：纳米颗粒，其他物理形式和与酸的溶解性的发展

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摘要

Chitosan is a modified form of Chitin. It is a modified carbohydrate polymer derived by hydrolyzing the aminoacetyl groups of chitin. Chitosan is a biodegradable natural polymer which is, biocompatible, non-toxic. It also shows anti-bacterial properties. This polysaccharide is available in different forms such as nanoparticles, solution, powder, flake, fiber, film, etc. Due to its wide range of physical forms and good reactivity with other compounds, chitosan can produce various blends. Nanoparticles of various natural biopolymers have emerged as potential carrier for drugs in oral controlled drug delivery. Nanostructured drug carriers allow the delivery of not only small-molecule drugs but also of nucleic acids and proteins. Chemical modification of nanoparticles of chitosan is useful for the association of bioactive molecules to polymer and controlling the drug release profile. In recent years focus on chitosan is shifted to its derivatives. This versatile material has broad applications in many different fields. Various physical forms of chitosan and its blends together with other derivatives such as composites and graft copolymers have been developed to overcome limitations of different polymeric materials such as poor mechanical properties and to improve its functionality towards specific applications. Nanoparticles of chitosan and it derivatives are extensively exploited in the field of oral drug delivery. The progress made in converting chitosan and its blends into nanoparticles forms as well as the preparation methods are studied. For preparation of these blends and nanoparticles of chitosan need to be dissolved in for reactions. We also studied its dissolution behavior with different acids. It shows quite interesting results.
机译：壳聚糖是甲壳质的修饰形式。它是通过水解几丁质的氨基乙酰基衍生的改性碳水化合物聚合物。壳聚糖是可生物降解的天然聚合物，具有生物相容性，无毒。它还显示出抗菌特性。这种多糖有不同的形式，例如纳米颗粒，溶液，粉末，薄片，纤维，薄膜等。由于其广泛的物理形式和与其他化合物的良好反应性，壳聚糖可以生产各种混合物。各种天然生物聚合物的纳米颗粒已经成为口服控制药物递送中潜在的药物载体。纳米结构的药物载体不仅可以递送小分子药物，还可以递送核酸和蛋白质。壳聚糖纳米颗粒的化学修饰可用于生物活性分子与聚合物的缔合和控制药物释放曲线。近年来，对壳聚糖的关注已转向其衍生物。这种通用材料在许多不同领域中都有广泛的应用。已经开发了各种物理形式的壳聚糖及其共混物以及其他衍生物，例如复合材料和接枝共聚物，以克服不同聚合物材料的局限性，例如较差的机械性能，并改善其在特定应用中的功能。壳聚糖及其衍生物的纳米颗粒在口服药物递送领域中被广泛开发。研究了壳聚糖及其共混物转化为纳米颗粒形式及其制备方法的进展。为了制备这些共混物和壳聚糖的纳米颗粒，需要将其溶解以进行反应。我们还研究了其在不同酸中的溶解行为。它显示出非常有趣的结果。

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