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Numerical Method on Drug Release from Nanoparticles using CFD

机译:CFD从纳米颗粒释放药物的数值方法

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摘要

Nowadays, there are many ways to administer the huge variety of drugs that are on the market. A drug is a chemical substance, that when applied to a living creature, alters its body function. Many drugs are used daily, such as caffeine in coffee and aspirin for pain. A route of drug administration in pharmacology and toxicology is the path by which a drug is brought into contact with the body. The most critical issue is some drugs are not significantly absorbed into the bloodstream. There are thousands of questions on the drug diffusion in the bloodstream and the most common issue is how long will these micro particles drug be released from the tablet? Thus, to identify the rate of the drug release and to control the drug release in our body is important, where to meet the target and not to become a waste. The Computational Fluid Dynamics method was used to investigate the drug design and diffusion profiles with time during the process of degradation and diffusion in water.
机译:如今,有许多方法可以管理市场上种类繁多的药物。药物是一种化学物质,当应用于生物时,会改变其身体功能。每天使用许多药物,例如咖啡中的咖啡因和阿司匹林以止痛。药理学和毒理学中的药物施用途径是使药物与人体接触的途径。最关键的问题是某些药物没有被血液充分吸收。关于药物在血液中扩散的问题有成千上万个,最常见的问题是这些微粒药物将从片剂中释放多长时间?因此,确定药物释放速率并控制我们体内的药物释放非常重要,要达到目标并避免浪费。在水中降解和扩散过程中,使用计算流体动力学方法研究了药物设计和扩散曲线随时间的变化。

著录项

  • 来源
    《Journal of nano research》 |2011年第2011期|p.61-68|共8页
  • 作者单位

    Department of Chemical and Environmental EngineeringFaculty of Engineering, Universiti Putra MalaysiaSerdang, 43400 UPM, Serdang Selangor,Malaysia;

    Department of Chemical and Environmental EngineeringFaculty of Engineering, Universiti Putra MalaysiaSerdang, 43400 UPM, Serdang Selangor,Malaysia;

    Department of Chemical and Environmental EngineeringFaculty of Engineering, Universiti Putra MalaysiaSerdang, 43400 UPM, Serdang Selangor,Malaysia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    drug; cfd; nanoparticles; diffusion; release; profile.;

    机译:药品;cfd;纳米粒子扩散;释放;轮廓。;

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