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首页> 外文期刊>Journal of Nanoparticle Research >Polyol-synthesized Zn0.9Mn0.1S nanoparticles as potential luminescent and magnetic bimodal imaging probes: synthesis, characterization, and toxicity study
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Polyol-synthesized Zn0.9Mn0.1S nanoparticles as potential luminescent and magnetic bimodal imaging probes: synthesis, characterization, and toxicity study

机译：多元醇合成的Zn 0.9 Mn 0.1 S纳米粒子作为潜在的发光和磁双峰成像探针：合成，表征和毒性研究

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摘要

We report here the synthesis, by the polyol method, of Mn-doped ZnS nanocrystals with the zinc blende structure. Phase transfer of the as-produced quantum dots from organic solvent into water was achieved by surface complexation with mercaptoacetate ligands. The magnetic and optical properties of the powders and aqueous colloids obtained were evaluated by SQUID magnetometry as well as electronic absorption and emission spectroscopies, to test their potential as magnetic and luminescent bimodal probes for medical imaging. With a 10 % concentration of Mn2+, the nanoparticles are paramagnetic at body temperature, and the aqueous colloids they form have high relaxivity with a r 1 value of 20 mM−1 s−1 at 3 T. They are highly luminescent with a blue–green emission on 405-nm excitation. Viability assays and genotoxicity tests on Chinese hamster ovarian cells revealed neither acute cellular death, nor cell toxicity, nor damage to the nucleus after exposure for 24 h to particle doses of up to 100 μg mL−1.
机译：我们在这里报告通过多元醇法合成具有锌共混物结构的Mn掺杂的ZnS纳米晶体。所产生的量子点从有机溶剂到水中的相转移是通过与巯基乙酸酯配体的表面络合实现的。通过SQUID磁力分析以及电子吸收和发射光谱对获得的粉末和水性胶体的磁性和光学性质进行了评估，以测试它们作为医学成像的磁性和发光双峰探针的潜力。在Mn 2 + 浓度为10％的情况下，纳米粒子在体温下是顺磁性的，它们形成的水性胶体具有很高的弛豫性，ar 1 值为20 mM -1 s -1 。它们在405 nm激发下具有高发光强度，并发出蓝绿色光。在中国仓鼠卵巢细胞上进行的活力测定和遗传毒性测试显示，暴露于剂量最高为100μgmL -1 的颗粒24小时后，既没有急性细胞死亡，也没有细胞毒性，也没有对细胞核的损害。

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