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首页> 外文期刊>Journal of neural engineering >Electrode fabrication and interface optimization for imaging of evoked peripheral nervous system activity with electrical impedance tomography (EIT)
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Electrode fabrication and interface optimization for imaging of evoked peripheral nervous system activity with electrical impedance tomography (EIT)

机译：电极制造和界面优化，可通过电阻抗断层扫描（EIT）对诱发的周围神经系统活动进行成像

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016001.1-016001.11%Objective. Non-invasive imaging techniques are undoubtedly the ideal methods for continuous monitoring of neural activity. One such method, fast neural electrical impedance tomography (EIT) has been developed over the past decade in order to image neural action potentials with non-penetrating electrode arrays. Approach. The goal of this study is two-fold. First, we present a detailed fabrication method for silicone-based multiple electrode arrays which can be used for epicortical or neural cuff applications. Secondly, we optimize electrode material coatings in order to achieve the best accuracy in EIT reconstructions. Main results. The testing of nanostructured electrode interface materials consisting of platintun, iridium oxide, and PEDOT:pTS in saline tank experiments demonstrated that the PEDOT:pTS coating used in this study leads to more accurate reconstruction dimensions along with reduced phase separation between recording channels. The PEDOT:pTS electrodes were then used in vivo to successfully image and localize the evoked activity of the recurrent laryngeal fascicle from within the cervical vagus nerve. Significance. These results alongside the simple fabrication method presented here position EIT as an effective method to image neural activity.
机译：016001.1-016001.11％目标。无创成像技术无疑是连续监测神经活动的理想方法。在过去的十年中，已经开发了一种这样的方法，即快速神经电阻抗断层扫描（EIT），以利用非穿透性电极阵列对神经动作电位进行成像。方法。这项研究的目标是双重的。首先，我们为基于有机硅的多电极阵列提供了一种详细的制造方法，该方法可用于皮层或神经袖套应用。其次，我们优化电极材料涂层，以在EIT重建中获得最佳精度。主要结果。在盐罐实验中对由铂金屯，氧化铱和PEDOT：pTS组成的纳米结构电极界面材料的测试表明，本研究中使用的PEDOT：pTS涂层可导致更准确的重建尺寸，并减少记录通道之间的相分离。然后将PEDOT：pTS电极用于体内，以成功成像并定位子宫颈迷走神经内的喉返束的诱发活动。意义。这些结果与此处介绍的简单制造方法一起，将EIT定位为对神经活动进行成像的有效方法。

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