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首页> 外文期刊>Journal of neural engineering >Capacitive-like photovoltaic epiretinal stimulation enhances and narrows the network-mediated activity of retinal ganglion cells by recruiting the lateral inhibitory network
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Capacitive-like photovoltaic epiretinal stimulation enhances and narrows the network-mediated activity of retinal ganglion cells by recruiting the lateral inhibitory network

机译：像电容一样的光伏前视网膜刺激通过募集侧向抑制网络来增强和缩小视网膜神经节细胞的网络介导活性

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Photovoltaic retinal prostheses theoretically offer the possibility of stand-alone high-resolution electrical stimulation of the retina. However, achieving focused epiretinal stimulation is particularly challenging because of axonal activation and electrical cell coupling. Recent evidence shows that long electric pulses permit a more focal activation of retinal ganglion cells, and non-rectangular waveforms induce higher network-mediated indirect activity. Objective. The role of the pulse shape in focusing the retinal ganglion cell activation and the underlying mechanisms are not yet fully understood. Approach. To address this question, we implemented a hybrid ex vivo and in silico approach. We recorded the evoked activity of retinas explanted from retinal degeneration ten mice upon photovoltaic and electrical stimulation with rectangular or non-rectangular capacitive-like voltage pulses. We used a biophysical model to investigate the role of the pulse shape and the pulse duration on the genesis and the extent of the network-mediated activity in retinal ganglion cells. Main results. Altogether, our results suggest that non-rectangular capacitive-like voltage pulses activate more strongly the inner excitatory and inhibitory layers of the retina, when compared to a rectangular stimulation with paired pulse amplitude and duration. This feature leads to an increase of the network-mediated activity and a decrease in the network-mediated electrical receptive field of the stimulated retinal ganglion cell. Significance. These results demonstrate that recruiting the inner retinal cells with epiretinal stimulation enables us not only to bypass axonal stimulation, but also to obtain a more focal activation due to the natural lateral inhibition. The involvement of the inhibitory feedback from amacrine cells in the genesis of the network-mediated activity represents a novel biological tool with which to confine the response of the retinal ganglion cells. These results support future waveform engineering strategies and offer new perspectives on epiretinal devices to better shape prosthetic perception.
机译：理论上，光伏视网膜假体提供了对视网膜进行独立高分辨率电刺激的可能性。然而，由于轴突激活和细胞偶联，实现聚焦的视网膜前刺激特别具有挑战性。最近的证据表明，长的电脉冲可以使视网膜神经节细胞更具聚焦性，而非矩形波形则可以诱导更高的网络介导的间接活性。目的。脉冲形状在聚焦视网膜神经节细胞激活中的作用及其潜在的机制尚未完全了解。方法。为了解决这个问题，我们实施了体外和计算机混合的方法。我们记录了由矩形或非矩形电容式电压脉冲对光电和电刺激后从视网膜变性十只小鼠移植的视网膜的诱发活动。我们使用生物物理模型来研究脉搏形状和脉搏持续时间对视网膜神经节细胞的起源和网络介导的活动程度的作用。主要结果。总的来说，我们的结果表明，与具有成对脉冲幅度和持续时间的矩形刺激相比，非矩形电容样电压脉冲可以更强烈地激活视网膜的内部兴奋性和抑制性层。该特征导致受刺激的视网膜神经节细胞的网络介导的活性增加和网络介导的电感受野的降低。意义。这些结果表明，通过前视网膜刺激募集内部视网膜细胞不仅使我们能够绕过轴突刺激，而且由于自然的侧向抑制作用而获得更多的局部激活。来自无长突细胞的抑制性反馈参与网络介导的活性的产生代表了一种新颖的生物学工具，用它来限制视网膜神经节细胞的反应。这些结果支持未来的波形工程策略，并为视网膜成形术提供了新的视角，以更好地塑造假体的感知。

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