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首页> 外文期刊>Journal of Neural Transmission >Preparation and properties of nanoscale containers for biomedical application in drug delivery: preliminary studies with kynurenic acid
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Preparation and properties of nanoscale containers for biomedical application in drug delivery: preliminary studies with kynurenic acid

机译：用于药物递送的生物医学应用纳米级容器的制备和性能：犬尿酸的初步研究

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摘要

The main purpose of this study was to facilitate the delivery of kynurenic acid (KYNA) across the blood–brain barrier (BBB) by applying micelles as nanoscale containers. Non-ionic amphiphilic molecules were used for preparation of spherical micelles for delivery of kynurenic acid in aqueous solution in physiological condition. It was established that Triton X 100 and Lutensol AP 20 non-ionic surfactants are able to produce stable nanocontainers for delivery of kynurenic acid molecules. The incorporation of KYNA molecules was investigated by dynamic light scattering and the size of micelles were calculated between 5 and 10 nm in 150 mM NaCl and pH 7.5–7.6 solutions. Encapsulated kynurenic acid showed a significantly higher blood–brain barrier permeability compared with non-encapsulated kynurenic acid. The in vivo experiments showed that the encapsulated kynurenic acid is able to display effects within the central nervous system, even after its peripheral administration.
机译：这项研究的主要目的是通过将胶束用作纳米级容器来促进血尿酸（KYNA）跨血脑屏障（BBB）的传递。非离子两亲性分子用于制备球形胶束，用于在生理条件下在水溶液中递送健尿酸。已经确定，Triton X 100和Lutensol AP 20非离子表面活性剂能够生产稳定的纳米容器，用于递送动尿酸分子。通过动态光散射研究了KYNA分子的掺入，并在150 mM NaCl和pH 7.5-7.6溶液中计算了5至10 nm之间的胶束大小。与非胶囊化的犬尿酸相比，胶囊化的犬尿酸显示出更高的血脑屏障通透性。体内实验表明，封装的犬尿酸即使在外周给药后也能在中枢神经系统内发挥作用。

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  • 来源
    《Journal of Neural Transmission》 |2012年第2期|p.115-121|共7页
  • 作者

    V. Hornok; T. Bujdosó; J. Toldi; K. Nagy; I. Demeter; C. Fazakas; I. Krizbai; L. Vécsei; I. Dékány;

  • 作者单位

    Supramolecular and Nanostructured Materials Research Group of the Hungarian Academy of Sciences, Faculty of Medicine, Institute of Medical Chemistry, and Nanomedicine Program, University of Szeged, Aradi v.t.1, Szeged, 6720, Hungary;

    Supramolecular and Nanostructured Materials Research Group of the Hungarian Academy of Sciences, Faculty of Medicine, Institute of Medical Chemistry, and Nanomedicine Program, University of Szeged, Aradi v.t.1, Szeged, 6720, Hungary;

    Deparment of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary;

    Deparment of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary;

    Deparment of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary;

    Institute of Biophysics, Biological Research Centre of the Hungarian Acad;

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  • 正文语种 eng
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  • 关键词

    Non-ionic surfactants; Micelles; Kynurenic acid; Nanocontainers; Blood–brain barrier; Encapsulation;

    机译：非离子表面活性剂;胶束;犬尿酸;纳米容器;血脑屏障;封装;

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