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首页> 外文期刊>Journal of Neurology >REM sleep behavior disorder in Japanese patients with Parkinson’s disease: a multicenter study using the REM sleep behavior disorder screening questionnaire
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REM sleep behavior disorder in Japanese patients with Parkinson’s disease: a multicenter study using the REM sleep behavior disorder screening questionnaire

机译：日本帕金森氏病患者的REM睡眠行为障碍：一项使用REM睡眠行为障碍筛查问卷的多中心研究

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REM sleep behavior disorder (RBD) is known to be observed more frequently in patients with an α-synucleinopathy such as Parkinson’s disease (PD) than in the general population. The precise prevalence of RBD in Japanese PD patients is not known. Therefore, we investigated the prevalence and the clinical characteristics of patients with RBD in a large population of Japanese patients with PD. We investigated various clinical features and employed the Japanese version of the RBD screening questionnaire on 469 non-demented Japanese PD patients in this multicenter study. Probable or possible RBD was detected in 146 patients (31.1%) and was significantly associated with longer PD duration, higher Hoehn and Yahr stage, higher Unified Parkinson’s Disease Rating Scale part III subscale (7 items), more motor fluctuations, and a higher levodopa-equivalent daily dose (p 0.01). As to the major autonomic dysfunctions, severe constipation was significantly more frequent in PD patients with RBD than in those without it (p 0.01). The RBD symptoms of 53 patients (39.0%) preceded the onset of PD motor symptoms. The median interval from the onset of RBD symptoms to PD motor symptoms was 17.5 years, and 3 patients had intervals of over 50 years. This large-scale multicenter study revealed that RBD is a frequent non-motor symptom in Japanese patients with PD, which may precede the onset of motor symptoms. Moreover, RBD that increases with the duration and severity of PD may be associated with autonomic dysfunction.
机译：众所周知，患有REM综合征的帕金森氏病（PD）患者的REM睡眠行为障碍（RBD）发病率要高于普通人群。尚不清楚日本PD患者中RBD的确切患病率。因此，我们调查了日本PD患者中RBD患者的患病率和临床特征。在这项多中心研究中，我们调查了各种临床特征，并对469名非痴呆的日本PD患者采用了日语版的RBD筛查问卷。在146例患者中检测到可能或可能存在的RBD（31.1％），并与更长的PD持续时间，较高的Hoehn和Yahr分期，较高的帕金森病统一疾病分级量表（Part III）次级量表（7项），更多的运动波动和较高的左旋多巴相关-等效每日剂量（p <0.01）。关于主要的自主神经功能障碍，有RBD的PD患者的严重便秘发生率明显高于无RBD的患者（p <0.01）。 53例患者（39.0％）的RBD症状先于PD运动症状发作。从RBD症状发作到PD运动症状的中位间隔为17.5年，其中3例间隔超过50年。这项大规模的多中心研究表明，RBD是日本PD患者的一种常见的非运动症状，可能早于运动症状发作。此外，随着PD持续时间和严重程度的增加而增加的RBD可能与自主神经功能障碍有关。

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