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首页> 外文期刊>Journal of Neurology >Stem cell transplantation in multiple sclerosis
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Stem cell transplantation in multiple sclerosis

机译:干细胞移植治疗多发性硬化症

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Following promising results in animal studies showing that immunosuppression and consecutive allogeneic bone marrow transplantation has the potential to significantly reduce autoimmunity, emerging data is supporting a benefit in patients with multiple sclerosis (MS) and other autoimmune disorders not responding to approved therapies. Until today, results on over 400 cases have been reported by the European Blood and Marrow Transplantation Group (EBMT), many of them with a favorable outcome. However, results of randomized, controlled clinical trials are missing. Furthermore, with upcoming new treatment compounds that to some extent act via lymphoablative properties, it remains essential to better select those patients who might profit most from stem cell therapy based on a justifiable benefit-to-risk ratio.
机译:在动物研究中令人鼓舞的结果表明免疫抑制和连续同种异体骨髓移植有可能显着降低自身免疫性之后,新出现的数据正在支持多发性硬化症(MS)和其他对已批准疗法无反应的自身免疫性疾病的患者的获益。到今天为止,欧洲血液和骨髓移植小组(EBMT)已报告了400余例病例的结果,其中许多结果都令人满意。但是,缺少随机对照临床试验的结果。此外,对于即将在某种程度上通过淋巴消融作用发挥作用的新型治疗化合物,仍然有必要根据合理的风险比,更好地选择那些可能从干细胞治疗中受益最大的患者。

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