...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neurology >Tremor in multiple sclerosis
【24h】

Tremor in multiple sclerosis

机译：多发性硬化症的震颤

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tremor is estimated to occur in about 25 to 60 percent of patients with multiple sclerosis (MS). This symptom, which can be severely disabling and embarrassing for patients, is difficult to manage. Isoniazid in high doses, carbamazepine, propranolol and gluthetimide have been reported to provide some relief, but published evidence of effectiveness is very limited. Most trials were of small size and of short duration. Cannabinoids appear ineffective. Tremor reduction can be obtained with stereotactic thalamotomy or thalamic stimulation. However, the studies were small and information on long-term functional outcome is scarce. Physiotherapy, tremor reducing orthoses, and limb cooling can achieve some functional improvement. Tremor in MS remains a significant challenge and unmet need, requiring further basic and clinical research.
机译：据估计，多发性硬化症（MS）患者中约有25％至60％发生震颤。这种症状可能会使患者严重瘫痪并使之尴尬，难以控制。据报道，高剂量异烟肼，卡马西平，普萘洛尔和谷氨酰胺可缓解某些症状，但已发表的有效性证据十分有限。大多数试验规模较小且持续时间短。大麻素似乎无效。立体定向丘脑或丘脑刺激可减少震颤。但是，研究规模很小，并且缺乏有关长期功能结局的信息。物理疗法，减少震颤的矫形器和肢体冷却可以改善某些功能。 MS的震颤仍然是一项重大挑战，尚未满足，需要进一步的基础和临床研究。

著录项

  • 来源
    《Journal of Neurology》 |2007年第2期|133-145|共13页
  • 作者

    Marcus Koch MD; Jop Mostert MD; Dorothea Heersema MD PhD; Jacques De Keyser MD PhD;

  • 作者单位

    Dept. of Neurology University Medical Centre Groningen University of Groningen Hanzeplein 1 9713 GZ Groningen The Netherlands;

    Dept. of Neurology University Medical Centre Groningen University of Groningen Hanzeplein 1 9713 GZ Groningen The Netherlands;

    Dept. of Neurology University Medical Centre Groningen University of Groningen Hanzeplein 1 9713 GZ Groningen The Netherlands;

    Dept. of Neurology University Medical Centre Groningen University of Groningen Hanzeplein 1 9713 GZ Groningen The Netherlands;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    multiple sclerosis; treatment; tremor; ataxia;

    机译：多发性硬化症;治疗;震颤;共济失调;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号