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首页> 外文期刊>Journal of Oleo Science >Effect of Peucedanum japonicum Thunb Extract on High-fat Diet-induced Obesity and Gene Expression in Mice
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Effect of Peucedanum japonicum Thunb Extract on High-fat Diet-induced Obesity and Gene Expression in Mice

机译：白Pe提取物对高脂饮食诱导的肥胖和小鼠基因表达的影响

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摘要

Supplementation of the diet with Peucedanum japonicum Thunb (PJT) powder inhibits high-fat diet-induced obesity in mice. Either the fiber component or other bioactive components in the PJT powder may inhibit obesity. This study, therefore, was an attempt to identify the components, fiber or other phytochemicals of PJT that were responsible for the anti-obesity activity, and also studied the modulation of obesity-related gene expression in C57BL/6 mice. Animals were fed a modified-AIN76 diet supplemented with PJT powder or extracts of PJT in water, 50 % ethanol, or ethanol. Body weight gain, tissue weight, serum biochemical parameters, liver lipid concentrations, and gene expression in tissues were compared between the control and treatment groups. Of the extracts, the ethanol extract of PJT decreased fat accumulation and adipocyte size, reduced serum and liver triglyceride concentrations, and inhibited obesity. This finding clearly demonstrates the presence of anti-obesity phytochemicals in PJT. Ethanol extract of PJT inhibited lipase activity in vitro. Modulation of gene expression by PJT ethanol extract was largely similar to that by PJT powder in the hepatic and adipose tissues: RORC and PBEF1 were upregulated and DUSP1, INSIG2, and SERPINA12 were downregulated in the liver; FXRa and PPARy were upregulated and PEG1/MEST, the size-marker of adipocytes, was downregulated in the adipose tissue. Furthermore, PJT ethanol extract increased the expression of the UCP3 gene in muscle. These results suggest that the anti-obesity phytochemicals in PJT lower lipid levels by inhibiting fat absorption and by modulating obesity-related gene expression in the liver, adipose tissue, and muscle.
机译：在日粮中添加白花前胡（PJT）粉末可抑制高脂饮食诱发的小鼠肥胖。 PJT粉末中的纤维成分或其他生物活性成分均可抑制肥胖。因此，这项研究是试图确定负责抗肥胖活性的PJT的成分，纤维或其他植物化学物质，并且还研究了C57BL / 6小鼠中与肥胖相关的基因表达的调控。给动物喂食改良的-AIN76饮食，该饮食补充有PJT粉末或PJT的水，50％乙醇或乙醇提取物。比较对照组和治疗组的体重增加，组织重量，血清生化参数，肝脂质浓度和组织中的基因表达。在提取物中，PJT的乙醇提取物减少了脂肪积累和脂肪细胞大小，降低了血清和肝脏甘油三酸酯的浓度，并抑制了肥胖症。这一发现清楚地证明了PJT中存在抗肥胖植物化学物质。 PJT的乙醇提取物在体外抑制脂肪酶活性。 PJT乙醇提取物对肝和脂肪组织中基因表达的调控与PJT粉末的调控非常相似：肝脏中RORC和PBEF1上调，而DUSP1，INSIG2和SERPINA12则下调。脂肪组织中的FXRa和PPARγ被上调，而脂肪细胞的大小标志物PEG1 / MEST被下调。此外，PJT乙醇提取物增加了UCP3基因在肌肉中的表达。这些结果表明，PJT中的抗肥胖植物化学物质可通过抑制脂肪吸收并调节肝脏，脂肪组织和肌肉中与肥胖相关的基因表达来降低脂质水平。

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  • 来源
    《Journal of Oleo Science》 |2012年第2期|p.89-101|共13页
  • 作者

    Natthanan Nukitrangsan; Takafumi Okabe; Takayoshi Toda; Masashi Inafuku; Hironori Iwasaki; Hirosuke Oku;

  • 作者单位

    United Graduate School of Agricultural Sciences, Kagoshima University, (Korimoto1-21-24, Kagoshima 890-0065, JAPAN),Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus (Senbaru 1, Nishihara, Okinawa 903-0213, JAPAN);

    Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus (Senbaru 1, Nishihara, Okinawa 903-0213, JAPAN);

    Department of Clinical Labolatory Medicine, School of Medicine, University of the Ryukyu Hospital (Uehara 207, Nishihara, Okinawa 903-0215, JAPAN);

    Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus (Senbaru 1, Nishihara, Okinawa 903-0213, JAPAN);

    Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus (Senbaru 1, Nishihara, Okinawa 903-0213, JAPAN);

    Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus (Senbaru 1, Nishihara, Okinawa 903-0213, JAPAN);

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  • 正文语种 eng
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  • 关键词

    anti-obesity; lipid metabolism; gene expression; peucedanum japonicum thunb extract;

    机译：减肥脂质代谢基因表达;皮提取物;

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