New electronic analogs of the sialyl cation: n-functionalized 4-acetamido-2,4-dihydroxypiperidines. Inhibition of bacterial sialidases

Ian B.Parr; Benjamin A.Horenstein

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New electronic analogs of the sialyl cation: n-functionalized 4-acetamido-2,4-dihydroxypiperidines. Inhibition of bacterial sialidases

机译：唾液酸阳离子的新电子类似物：n-官能化的4-乙酰氨基-2,4-二羟基哌啶。抑制细菌唾液酸酶

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摘要

Sialic acids (N-acetylneuraminic acid, NeuAc) are nine- carbon ketoses which have the unusual feature of a highly acidic carboxyl group (PK_a?2.8) immediately adjacent to the anomeric carbon. Sialic acids are typi- cally found in terminal glycosidic linkages of cell surface glycoproteins and glycolipids and are represented in species as diverse as bacteria, trypanosomes, and higher members of the animal kingdom, including humans.

机译：唾液酸（N-乙酰神经氨酸，NeuAc）是九碳酮糖，其具有与异头碳直接相邻的高酸性羧基（PK_a≤2.8）的不寻常特征。唾液酸通常存在于细胞表面糖蛋白和糖脂的末端糖苷键中，并且在细菌，锥虫和动物界的更高成员，包括人类中都有代表。

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《The Journal of Organic Chemistry》 |1997年第21期|p.7489-7494|共6页
作者
Ian B.Parr; Benjamin A.Horenstein;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类有机化学;
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1. Synthesis of a new transition-state analog of the sialyl donor. Inhibition of sialyltransferases [J] . Hongbin Sun, Jingsong Yang, Katie E.Amaral, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2001,第13期

机译：合成了新的唾液酸供体的过渡态类似物。唾液酸转移酶的抑制
2. Synthesis of PEGylated lactose analogs for inhibition studies on T.cruzi trans-sialidase [J] . M. Eugenia Giorgi, Laura Ratier, Rosalía Agusti, Glycoconjugate Journal . 2010,第5期

机译：聚乙二醇化乳糖类似物的合成用于抑制克鲁氏酵母转唾液酸酶的研究
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5. Organic materials utilizing first and second generation n-functionalized dithieno[3,2-b:2',3'-d]pyrroles: Synthesis, characterization, and application to electronic devices [D] . Evenson, Sean Justin 2012

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6. Inhibition of sialidase activity and cellular invasion by the bacterial vaginosis pathogen Gardnerella vaginalis [O] . G. Govinden, J. L. Parker, K. L. Naylor, -1

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7. Polymers of a Transition-State Sialyl Cation Strongly Inhibit Bacterial Sialidases. [O] . coralie assailly, clarisse bridot, amélie saumonneau, 2020

机译：过渡态SiaLyl阳离子的聚合物强烈抑制细菌唾液酸酶。
8. Design, Development, and Fabrication of a Electronic Analog Microminiaturized Electronic Analog Signal to Discrete Time Interval Converter [R] . Schoenfeld, A. D., Schuegraf, K. K. 1973

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New electronic analogs of the sialyl cation: n-functionalized 4-acetamido-2,4-dihydroxypiperidines. Inhibition of bacterial sialidases

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