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首页> 外文期刊>Journal of Parasitology >History of the Discovery of Sulfaquinoxaline as a Coccidiostat
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History of the Discovery of Sulfaquinoxaline as a Coccidiostat

机译：发现磺胺喹喔啉作为抗球虫药的历史

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Sulfaquinoxaline played an important part in the demotion of roast chicken from vaunted Sunday-dinner status to an unrespected position on the everyday menu of the Western world. It had its origins in the chemical synthetic program that sprang from the introduction of sulfonamide drugs into human medicine in the 1930s. The program was sustained through the years of World War II despite declining clinical use of that chemical class. Several sulfa drugs were known to be active against the sporozoan parasite (Plasmodium spp.) that causes malaria, but were not satisfactory in clinical practice. A sulfonamide that had a long plasma half-life would ipso facto be considered promising as an antimalarial drug. Sulfaquinoxaline, synthesized during the war, was such a compound. It proved too toxic to be used in human malaria, but was found to be a superior agent against another sporozoan parasite, Eimeria spp., the causative agent of coccidiosis in domestic chickens. In 1948 sulfaquinoxaline was introduced commercially as a poultry coccidiostat. It was not the first sulfonamide found active against Eimeria spp. in poultry, but its practical success in disease control firmly established the routine incorporation of anticoccidial drugs in poultry feed. In this way, the drug exerted a major impact on the worldwide production of poultry meat. Although it has long been eclipsed by other drugs in poultry management, it continues to be used in other host species. This article describes the discovery of sulfaquinoxaline as a practical therapeutic agent, and examines the way in which the discovery arose from a partnership between industry and academia.
机译：磺胺喹喔啉在将烤鸡从声称的周日晚餐状态降为西方世界日常菜单中不受欢迎的位置中发挥了重要作用。它的起源是化学合成程序，始于1930年代将磺酰胺药物引入人类医学。尽管该化学类别的临床使用有所减少，但该计划一直持续到第二次世界大战。已知几种磺胺类药物对引起疟疾的子孢子寄生虫（Plasmodium spp。）具有活性，但在临床实践中并不令人满意。实际上，具有较长血浆半衰期的磺酰胺将被认为是有前途的抗疟药。战争期间合成的磺胺喹喔啉就是这种化合物。它被证明毒性太大，无法在人类疟疾中使用，但被发现是对抗另一种子孢子虫Eimeria spp。（家禽球虫病的病原体）的优良药剂。 1948年，磺胺喹喔啉作为家禽抗球虫药投入市场。这不是第一个发现对艾美球虫属有活性的磺酰胺。在家禽中，但其在疾病控制方面的实际成功牢固地确立了在禽类饲料中常规加入抗球虫药的习惯。这样，该药物对禽肉的全球生产产生了重大影响。尽管它早已在家禽管理中被其他药物所取代，但仍继续用于其他寄主物种。本文介绍了磺胺喹喔啉作为一种实用治疗剂的发现，并探讨了该发现源于工业界和学术界之间的合作关系。

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