...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Parasitology >PROTECTION AGAINST MALARIA DUE TO INNATE IMMUNITY ENHANCED BY LOW-PROTEIN DIET
【24h】

PROTECTION AGAINST MALARIA DUE TO INNATE IMMUNITY ENHANCED BY LOW-PROTEIN DIET

机译：低蛋白饮食可增强免疫力，预防疟疾

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mice were fed ad libitum with a normal diet (25% protein) or low-protein diets (0–12.5% protein) for a wk and then infected with a nonlethal or lethal strain of Plasmodium yoelii, that is, blood stage infection. The same diet was continued until recovery. Mice fed with a normal diet showed severe parasitemia during nonlethal infection, but survived the infection. They died within 2 wk in the case of lethal infection. However, all mice fed with low-protein diets survived without apparent parasitemia (there were small peaks of parasitemia) in cases of both nonlethal and lethal strains. These surviving mice were found to have acquired potent innate immunity, showing the expansion of NK1.1−TCRint cells and the production of autoantibodies during malarial infection. Severe combined immunodeficiency (scid) mice, which lack TCRint cells as well as TCRhigh cells, did not survive after malarial infection of lethal strain of P. yoelii, even when low-protein diets were given. These results suggest that low-protein diets enhanced innate immunity and inversely decreased conventional immunity, and that these immunological deviations rendered mice resistant against malaria. The present outcome also reminds us of our experience in the field study of malaria, in which some inhabitants eventually avoided contracting malaria even after apparent malarial infection.
机译：随意给小鼠饲喂正常饮食（25％蛋白质）或低蛋白饮食（0–12.5％蛋白质），每周一次，然后感染约氏疟原虫的非致死性或致死性，即血液阶段感染。继续相同的饮食直至恢复。饲喂正常饮食的小鼠在非致死性感染期间显示出严重的寄生虫病，但在感染后存活了下来。在致命感染的情况下，他们在2周内死亡。但是，在非致死性和致死性毒株的情况下，所有饲喂低蛋白饮食的小鼠都没有明显的寄生虫病存活（寄生虫病峰很小）。发现这些幸存的小鼠具有强大的先天免疫力，显示在疟疾感染期间NK1.1-TCRint细胞的扩增和自身抗体的产生。缺乏TCRint细胞和高TCRhigh细胞的严重联合免疫缺陷（scid）小鼠，即使在给予低蛋白饮食的情况下，经疟原虫感染致死性约氏疟原虫后也无法存活。这些结果表明，低蛋白饮食能增强先天免疫力，而反过来会降低常规免疫力，这些免疫学偏差使小鼠对疟疾具有抵抗力。目前的结果也使我们想起了我们在疟疾现场研究中的经验，其中一些居民即使在明显的疟疾感染后也最终避免感染疟疾。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号