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首页> 外文期刊>Journal of Parasitology >COMPARATIVE EFFECT OF NEOSPORA CANINUM INFECTION IN BALB/c MICE AT THREE DIFFERENT GESTATION PERIODS
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COMPARATIVE EFFECT OF NEOSPORA CANINUM INFECTION IN BALB/c MICE AT THREE DIFFERENT GESTATION PERIODS

机译：三种不同孕育期新孢子虫感染对BALB / c小鼠的比较作用

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摘要

Neospora caninum has been recognized as a major cause of infectious bovine abortion worldwide. In the present study, the effect of N. caninum infection in mice at the 3 gestation periods (first, second, and third period) was investigated. In dams, tissue distribution of N. caninum was evaluated by nested polymerase chain reaction. In the progeny, fetal mortality, stillbirth, litter size, neonatal mortality/morbidity, vertical transmission, and parasite burden in neonatal tissues were evaluated. Pregnant BALB/c mice were infected subcutaneously with 2 × 106 NC-1 tachyzoites on days 0, 7, or 14 of gestation. Dams from each group were sequentially killed during gestation and postpartum (PP). Pups were killed on days 1 and 7 PP. Infection on day 0 of gestation produced a high vertical transmission rate, although no changes in fetal mortality, stillbirth, and littermate size were observed. The highest level of vertical transmission, together with an increase in fetal mortality and stillbirth and a decrease in litter size, were observed when infection was done on day 7 of gestation. Finally, infection on day 14 of gestation produced the lowest vertical transmission. Furthermore, infection at any time during gestation compromised the postnatal development of pups, because neonates from infected dams showed less body weight and a delay in the hair development.
机译：犬新孢子虫已被认为是全世界牛传染性流产的主要原因。在本研究中，研究了在三个妊娠期（第一，第二和第三期）对犬新孢子虫感染的影响。在大坝中，通过嵌套式聚合酶链反应评估犬新孢子虫的组织分布。在后代中，评估了胎儿死亡率，死产，产仔数，新生儿死亡率/发病率，垂直传播和新生儿组织中的寄生虫负担。在妊娠的第0、7或14天，用2×106 NC-1速殖子皮下感染怀孕的BALB / c小鼠。每个组的水坝在妊娠和产后（PP）期间被依次杀死。幼犬在PP第1天和第7天被杀死。尽管未观察到胎儿死亡率，死产和同窝仔数的变化，但在妊娠第0天的感染产生了较高的垂直传播率。在妊娠的第7天进行感染时，观察到最高水平的垂直传播，以及胎儿死亡率和死产的增加以及产仔数的减少。最后，在妊娠第14天的感染产生最低的垂直传播。此外，妊娠期任何时候的感染都会损害幼犬的产后发育，因为来自受感染母坝的新生儿体重减轻，头发发育延迟。

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