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首页> 外文期刊>Journal of Parasitology >HUMORAL IMMUNITY IS NOT CRITICAL FOR PROTECTION AGAINST EXPERIMENTAL INFECTION WITH SARCOCYSTIS NEURONA IN B-CELL–DEFICIENT MICE
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HUMORAL IMMUNITY IS NOT CRITICAL FOR PROTECTION AGAINST EXPERIMENTAL INFECTION WITH SARCOCYSTIS NEURONA IN B-CELL–DEFICIENT MICE

机译：对于抵抗B细胞缺乏症小鼠的神经性沙门氏菌的实验感染，免疫力的保护不是至关重要的

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Immunodeficient B-cell-deficient mice (mμMT) were infected with Sarcocystis neurona merozoites to determine the role of B cells and the humoral immune response in protective immunity. As expected, the mice did not seroconvert based on a direct agglutination test. Infected mice did not have significant changes in gross pathology at the time points examined. Histologic changes included mild perivascular and peribronchial infiltrate in the lungs; perivascular infiltrate and mild inflammatory sinusoidal foci in the liver; prominent high endothelial venules in the lymph nodes; and moderate cellular expansion of the periarteriolar sheaths (PALS) in the spleen. Changes resolved by day 60 postinfection. Mice developed significant CD4 and CD8 responses in lymphoid organs, including significant effector (CD45RBhigh) and memory (CD44high) CD4 and CD8 responses. Flow cytometry confirmed the lack of B cells. Overall, these data suggest that B cells are not critical to the protective immune response to SN infection.
机译：将免疫缺陷的B细胞缺陷小鼠（mμMT）感染了Sarcocystis Neurona裂殖子，以确定B细胞的作用和体液免疫应答在保护性免疫中的作用。不出所料，根据直接凝集试验，小鼠没有血清转换。在检查的时间点，感染小鼠的总体病理没有明显改变。组织学变化包括肺中轻度的血管周围和支气管周浸润；肝内血管周浸润和轻度炎症性窦房结；淋巴结中有明显的高内皮小静脉；脾中小动脉周围鞘（PALS）的中等细胞扩张。感染后第60天即可解决更改。小鼠在淋巴器官中产生了显着的CD4和CD8反应，包括显着的效应子（CD45RBhigh）和记忆（CD44high）CD4和CD8反应。流式细胞仪证实缺乏B细胞。总体而言，这些数据表明B细胞对于SN感染的保护性免疫应答并非至关重要。

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    《Journal of Parasitology》 |2005年第4期|p.00000830-00000837|共8页
  • 作者

    Sharon G. Witonsky Robert M. Gogal Jr.*‡ Robert B. Duncan Jr. Heather Norton Dan Ward† Jibing Yang and David S. Lindsay*;

  • 作者单位

    Department of Large Animal Clinical Sciences, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, Virginia 24061. switonsk@vt.edu*Center for Molecular Medicine and Infectious Disease, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, 1410 Prices Fork Rd., Virginia Tech, Blacksburg, Virginia 24061-0442†Research and Graduate Studies, Duck Pond Dr., Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, Virginia 24061-0442;

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