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首页> 外文期刊>Journal of Parasitology >EFFECT OF MOUSE STRAIN VARIATIONS AND CORTISONE TREATMENT ON THE ESTABLISHMENT AND GROWTH OF PRIMARY ECHINOCOCCUS MULTILOCULARIS HYDATID CYSTS
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EFFECT OF MOUSE STRAIN VARIATIONS AND CORTISONE TREATMENT ON THE ESTABLISHMENT AND GROWTH OF PRIMARY ECHINOCOCCUS MULTILOCULARIS HYDATID CYSTS

机译：小鼠应变变化和可的松治疗对原发性棘球CO多囊隐性囊肿建立和生长的影响

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摘要

The main purpose of this study was to determine the effects of cortisone on the number and size of primary Echinococcus multilocularis cysts developing in a moderately resistant strain of mice, i.e., C3H/HeJ. Computerized image analysis was used to measure the surface area occupied by hydatid cysts 10 wk after inoculation of the mice with E. multilocularis eggs. Our second objective was to compare the infectivity of primary E. multilocularis hydatid cysts in C57BL/6J-Ay/a (lethal yellow) mice with that in C57BL/6J-a/a (non-agouti black) mice. The data obtained show no difference between the C3H/HeJ and C57BL/6J-a/a strains of mice; yet, the image analysis method was able to detect a slight increase in the total cyst size within the Ay/a mutant of the C57BL/6J strain. Treatment of C3H/HeJ mice with cortisone drastically increased both the number of cysts and the average size of each cyst when the treatment occurred early in the infection.
机译：这项研究的主要目的是确定可的松对中度耐药小鼠C3H / HeJ中发育的原发多球棘球E虫囊肿数量和大小的影响。用计算机图像分析法测量用多叶眼肠球虫卵接种小鼠后10 wk包虫囊肿所占的表面积。我们的第二个目标是比较C57BL / 6J-Ay / a（致死黄）小鼠与C57BL / 6J-a / a（非agouti黑）小鼠的原发多囊葡萄球菌囊肿的感染性。获得的数据表明，C3H / HeJ和C57BL / 6J-a / a小鼠品系之间没有差异。然而，图像分析方法能够检测到C57BL / 6J菌株Ay / a突变体中总囊肿大小的轻微增加。当可的松对C3H / HeJ小鼠的治疗在感染早期发生时，极大地增加了囊肿的数量和每个囊肿的平均大小。

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    《Journal of Parasitology》 |2003年第3期|p.493-495|共3页
  • 作者

    M. B. Hildreth* and N. H. Granholm;

  • 作者单位

    Department of Biology and Microbiology, South Dakota State University, Brookings, South Dakota 57007. michael-hildreth@sdstate.edu;

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