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首页> 外文期刊>Journal of Parasitology >EFFECT OF DINITROANILINE HERBICIDES ON THE GROWTH OF ENTAMOEBA HISTOLYTICA
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EFFECT OF DINITROANILINE HERBICIDES ON THE GROWTH OF ENTAMOEBA HISTOLYTICA

机译：二硝基苯胺类除草剂对条状肠杆菌的生长的影响

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The effect of the dinitroaniline herbicides oryzalin and trifluralin on the growth of Entamoeba histolytica was examined. Oryzalin inhibited the growth of E. histolytica strain HM-1:IMSS. Trifluralin was less effective than oryzalin for this parasite. Entamoeba histolytica was more resistant to these dinitroanilines than other parasitic protozoa examined so far, including Leishmania spp., Trypanosoma brucei, Plasmodium falciparum, Toxoplasma gondii, and Cryptosporidium parvum. Colchicine, a potent microtubule inhibitor of animal cells, was much less effective for E. histolytica, even at very high concentrations. A reptilian parasite, Entamoeba invadens strain IP-1, examined for comparison, was more resistant to these dinitroanilines than E. histolytica. Accumulation of E. histolytica trophozoites in mitosis was observed after culture in 100 μM oryzalin. The inhibitory effect of oryzalin on the growth of E. histolytica trophozoites was abrogated by removal of the drug after exposure to 100 μM for 2 days. In parallel to the recovery of growth after removal of the drug, the percentage of trophozoites in mitosis was reduced to a normal level. The results indicate that treatment of trophozoites with oryzalin arrests mitosis and that its effect is reversible. Therefore, oryzalin is a useful tool for studies relating to the cell cycle of this parasite.
机译：考察了二硝基苯胺除草剂米扎林和三氟拉林对溶组织性变形虫的生长的影响。 Oryzalin抑制了溶组织性大肠杆菌HM-1：IMSS的生长。三氟拉林对这种寄生虫的疗效不如米扎林。到目前为止，溶组织性变形杆菌对这些二硝基苯胺的抵抗力比迄今检查的其他寄生原生动物（包括利什曼原虫，布鲁氏锥虫，恶性疟原虫，弓形虫和小隐孢子虫）更具抵抗力。秋水仙碱是一种有效的动物细胞微管抑制剂，即使在非常高的浓度下，对溶血性大肠杆菌的效果也要差得多。为了进行比较，对一种爬虫类寄生虫Entamoeba invadens入侵菌株IP-1进行了比较，其对这些二硝基苯胺的抗性比对溶组织性大肠杆菌的抗性高。在100μM的oryzalin中培养后，观察到有丝分裂大肠杆菌滋养体在有丝分裂中的积累。暴露于100μM2天后除去药物，从而消除了米草素对溶组织性大肠杆菌营养体的生长的抑制作用。与去除药物后生长的恢复并行，有丝分裂中滋养体的百分比降低至正常水平。结果表明，用稻草素处理滋养体可阻止有丝分裂，其作用是可逆的。因此，稻草素是用于研究与该寄生虫的细胞周期有关的有用工具。

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