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首页> 外文期刊>Journal of polymer engineering >Dual pH-/temperature-responsive and fluorescent hydrogel for controlled drug delivery
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Dual pH-/temperature-responsive and fluorescent hydrogel for controlled drug delivery

机译：双重pH /温度响应和荧光水凝胶可控制药物输送

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摘要

The purpose of this investigation is to develop a dual pH-/temperature-responsive and fluorescent hydrogel based on piperazine and Pluronic F127 (PF127). Firstly, polyurethane was synthesized using 1,6-hexamethylene diisocyanate, 1,4-bis(hydroxyethyl) piperazine, and PF127 by a step polymerization process. Erythrosine B (EB) is then incorporated into copolymers to offer a fluorescence property. The polyurethane-PF127-EB copolymer can spontaneously self-assemble into hydrogels with a great number of closely packed micelles, and the hydrogels also have the ability to undergo thermo-sensitive sol-gel phase transition above the critical gelation concentration. The gelation temperature can be adjusted near the physiological condition by modulating the - concentration of the copolymer in an aqueous medium. The acid--titration curves indicate a good pH-responsive property, and the UV-vis and fluorescence spectra exhibit strong self-fluorescence signals for hydrogels. As a result, the hydrogels not only can serve as drug carriers but can also be utilized as fluorescence imaging probes in biomedical applications.
机译：这项研究的目的是开发基于哌嗪和Pluronic F127（PF127）的双重pH /温度响应和荧光水凝胶。首先，使用1,6-六亚甲基二异氰酸酯，1,4-双（羟乙基）哌嗪和PF127通过分步聚合工艺合成聚氨酯。然后将赤藓红B（EB）掺入共聚物中以提供荧光性质。聚氨酯-PF127-EB共聚物可以自发​​地自组装成具有大量紧密堆积的胶束的水凝胶，并且水凝胶还具有在临界胶凝浓度以上进行热敏性溶胶-凝胶相变的能力。通过调节水性介质中共聚物的-浓度，可以将胶凝温度调节至接近生理条件。酸滴定曲线表明其具有良好的pH响应特性，而UV-vis和荧光光谱显示出强力的自凝胶荧光信号。结果，水凝胶不仅可以用作药物载体，而且还可以用作生物医学应用中的荧光成像探针。

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  • 来源
    《Journal of polymer engineering》 |2018年第4期|371-379|共9页
  • 作者

    Ye Wanli; Zhu Lidan; Xia Shan; Zhang Xiumei;

  • 作者单位

    Jilin Vocat Coll Ind & Technol, Jilin 132013, Jilin, Peoples R China;

    Changchun Univ Technol, Engn Res Ctr Synthet Resin & Special Fiber, Minist Educ, Changchun 130012, Jilin, Peoples R China;

    Changchun Univ Technol, Engn Res Ctr Synthet Resin & Special Fiber, Minist Educ, Changchun 130012, Jilin, Peoples R China;

    Jilin Univ, Dept Radiol, Hosp 1, Changchun 130021, Jilin, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    fluorescent; hydrogel; pH-/thermo-responsive; self-assemble;

    机译：荧光;水凝胶;pH /热响应;自组装;

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