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首页> 外文期刊>Journal of Polymers and the Environment >Synthesis and Characterization of a Novel phi-Sensitive Aluminum Crosslinked Carboxymethyl Tragacanth Beads for Extended and Enteric Drug Delivery
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Synthesis and Characterization of a Novel phi-Sensitive Aluminum Crosslinked Carboxymethyl Tragacanth Beads for Extended and Enteric Drug Delivery

机译：一种新型Phi敏感铝交联羧甲基TragaCanth珠粒延伸和肠道药物递送的合成与表征

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摘要

Carboxymethyl tragacanth (CM-TG) with a DS of 1.2 was synthesized and characterized for drug delivery using diclofenac sodium as a model drug. The mixture of CM-TG and drug was ionically crosslinked using aluminum chloride to form drug-loaded beads. The concentrations of 10 and 20%w/w solution of CM-TG were found to produce beads with acceptable qualities. The beads exhibited pH-dependent swelling. The highest swelling was observed at pH 6.8 which evidences the possibility to release the drug in the colon. FT-IR and TGA confirmed carboxymethylation of tragacanth and the absence of drug-polymer interaction. The diclofenac sodium entrapment efficiency was 30-35% while the loading varies from 4.5 to 18% w/w based upon the drug-polymer ratio. The beads could extend the drug release up to 180min at pH 6.8. The pH-responsive CM-TG hydrogel beads are biocompatible and could be exploited as a new excipient in developing enteric release formulations.
机译：用DS为1.2的羧甲基Tag（cm-Tg）合成，用双氯芬酸钠作为模型药物的药物递送。 CM-Tg和药物的混合物使用氯化铝离子交联，形成药物装载的珠粒。发现10和20％w / w的Cm-Tg溶液的浓度产生具有可接受的品质的珠子。珠子表现出pH依赖性肿胀。在pH 6.8中观察到最高肿胀，这证明了在结肠中释放药物的可能性。 FT-IR和TGA确认了葡萄状的羧甲基化和缺乏药物 - 聚合物相互作用。双氯芬钠夹产效率为30-35％，而负载基于药物 - 聚合物比例从4.5〜18％w / w。珠子可以将药物释放延伸至pH6.8的180分钟。 pH-响应性CM-Tg水凝胶珠粒是生物相容的，并且可以在开发肠释放制剂中被利用为新的赋形剂。

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