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首页> 外文期刊>Journal of Polymers and the Environment >Novel pH-Sensitive Hydrogel Beads Based on Carrageenan and Fish Scale Collagen for Allopurinol Drug Delivery
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Novel pH-Sensitive Hydrogel Beads Based on Carrageenan and Fish Scale Collagen for Allopurinol Drug Delivery

机译：基于角叉菜胶和鱼鳞胶原蛋白的新型pH敏感水凝胶珠子，用于Allopurinol药物递送

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摘要

In this work, pH-sensitive hydrogel beads based on fish scale collagen and carrageenan were used as a novel allopurinol drug loading system to improve the bioavailability of allopurinol, which is used to treat gout and high levels of uric acid in the human body. The effectiveness of the carrageenan/collagen/allopurinol hydrogel beads in improving the physical properties of allopurinol and the ability for drug release control in different simulated body fluids were evaluated by infrared (IR) spectroscopy, field emission scanning electron microscopy (FESEM), differential scanning calorimetry (DSC), dynamic light scattering (DLS) and Ultraviolet-Vis (UV-Vis) spectroscopy. In addition, the ability of hydrogen bond formation between allopurinol, carrageenan and collagen was calculated theoretically based on the B3LYP/6-31+g(d)//B3LYP/6-311++g(d,p) level of theory. Both the theoretical and experimental results proved that the hydrogen bonds of the functional groups in allopurinol with the functional groups in carrageenan and fish scale collagen contributed to the enhancement of drug release control as well as to the bioavailability of allopurinol loaded into the carrageenan/collagen hydrogel beads. The dissolution of carrageenan/collagen/allopurinol hydrogel beads in different simulated body fluids increased by 1.6 to 6.7 times compared to that of crystalline allopurinol.[GRAPHICS].
机译：在这项工作中，基于鱼鳞和角叉菜胶的pH敏感水凝胶珠作为新的Allopurinol药物载量系统，以改善Allopurinol的生物利用度，其用于治疗人体中的痛风和高水平的尿酸。通过红外（IR）光谱法评估角叉菜胶/肺蛋白/ Allopurinol Hydrogel珠粒在改善不同模拟体液中的物理性质以及在不同模拟体液中的药物释放控制能力，场发射扫描电子显微镜（FESEM），差示扫描量热法（DSC），动态光散射（DLS）和紫外 - VI（UV-VI）光谱。此外，基于B3LYP / 6-31 + G（d）// B3Lyp / 6-311 ++ g（d，p）理论水平，理论地计算含嘌呤醇，角叉菜胶和胶原醇之间的氢键形成能力。理论和实验结果证明，阿仑嘌呤醇中官能团的氢键与角叉菜胶和鱼鳞胶原蛋白的官能团有助于提高药物释放控制以及均多嘌呤醇的增强，负载到角叉菜胶/胶原水凝胶中珠子。与结晶Allopurinol相比，不同模拟体液中的角烷蛋白/胶原醛/ Allopurinol水凝胶珠粒的溶解增加1.6至6.7倍。[图形]。

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  • 来源
    《Journal of Polymers and the Environment》 |2020年第6期|1795-1810|共16页
  • 作者

    Nguyen Chinh Thuy; Vu Manh Quoc; Phan Thuy Thi; Vu Trung Quoc; Vo Quan An; Bach Giang Long; Thai Hoang;

  • 作者单位

    Vietnam Acad Sci & Technol Inst Trop Technol 18 Hoang Quoc Viet Hanoi 100000 Vietnam|Vietnam Acad Sci & Technol Grad Univ Sci & Technol 18 Hoang Quoc Viet Hanoi 100000 Vietnam;

    Vietnam Acad Sci & Technol Grad Univ Sci & Technol 18 Hoang Quoc Viet Hanoi 100000 Vietnam;

    Vinh Univ 182 Le Duan Vinh City 460000 Nghe An Vietnam;

    Hanoi Natl Univ Educ Fac Chem 136 Xuan Thuy Rd Hanoi 100000 Vietnam;

    Vietnam Acad Sci & Technol Inst Trop Technol 18 Hoang Quoc Viet Hanoi 100000 Vietnam;

    Nguyen Tat Thanh Univ NTT Inst High Technol 300A Nguyen Tat Thanh Dist 4 Ho Chi Minh 700000 Vietnam;

    Vietnam Acad Sci & Technol Inst Trop Technol 18 Hoang Quoc Viet Hanoi 100000 Vietnam|Vietnam Acad Sci & Technol Grad Univ Sci & Technol 18 Hoang Quoc Viet Hanoi 100000 Vietnam;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Fish scale collagen; pH-sensitive hydrogel beads; In vitro drug release; Hydrogen bonding; Allopurinol;

    机译：鱼鳞胶原蛋白;pH敏感水凝胶珠;体外药物释放;氢键;Allopurinol;

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