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首页> 外文期刊>Journal of Polymers and the Environment >Preparation, Characterization and Antibacterial Evaluation of Soy Protein Isolate Biopolymeric Films Loaded with Nalidixic Acid
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Preparation, Characterization and Antibacterial Evaluation of Soy Protein Isolate Biopolymeric Films Loaded with Nalidixic Acid

机译：用萘丙酸负载的大豆蛋白分离生物聚合物薄膜的制备，表征和抗菌评价

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摘要

Glycerol plasticized soy protein isolate (SPI) films at different contents (1 to 5% w/w w.r.t SPI) of nalidixic acid (NA) were fabricated by solution casting method. SPI films and NA incorporated SPI films were structurally and mechanically characterized by Fourier transform infrared spectroscopy (FTIR) and mechanical properties, respectively. Thermomechanical and water uptake studies were also carried out for NA incorporated SPI films. The results from FTIR study indicated the presence of NA in SPI as evidenced by generation of two additional peaks at 1259 cm(- 1) and 800 cm(- 1) attributed to C-C stretching vibration and the deformation of the heterocyclic aromatic ring, respectively. At 4% NA, the tensile stress and tensile modulus of SPI films increased from 5.18 MPa to 8.57 MPa and 57.14 MPa to 93.90 MPa, respectively. Antibacterial activity of NA incorporated SPI films against E. coli and L. monocytogenes were studied. The antibacterial studies of NA incorporated SPI film showed the clear zone of inhibition against both the bacteria. Docking studies were performed for SPI in order to evaluate their binding affinity with NA and similar type of aromatic acids such as mandelic and benzilic acid with which SPI films have been prepared earlier by our group. After docking, the ligands in form of aromatic acids were evaluated according to their binding energy and the interaction pattern between SPI and aromatic acids. The docking results indicated that nitrogen containing heterocyclic ring moiety remained intact during interaction of SPI and NA. This work will be helpful in fabricating NA incorporated SPI film from the renewable resources with significant antibacterial properties and reasonable mechanical properties.
机译：通过溶液浇铸方法制造不同内容物（NALIDIXIC酸（NA）的不同内容物（1至5％W / W.R.T SPI）的甘油增塑酪蛋白分离物（SPI）膜。通过傅里叶变换红外光谱（FTIR）和机械性能，在结构上和机械地表征SPI薄膜和Na Incorporated Spi薄膜。对于NA Incorporated SPI薄膜也进行了热机械和水吸收研究。 FTIR研究的结果表明了SPI中的Na的存在，其在1259cm（ - 1）和800cm（ - 1）的两种另外的峰分别归因于C-C拉伸振动和杂环芳环的变形。在4％Na中，SPI膜的拉伸应力和拉伸模量分别从5.18MPa增加到8.57MPa和57.14MPa至93.90MPa增加。研究了Na掺入的SPI薄膜对大肠杆菌和L.单核细胞生成的抗菌活性。 Na掺入的SPI膜的抗菌研究显示抑制细菌的透明区域。对SPI进行了对接研究，以评估与Na和类似类型的芳族酸如伪星和苯甲酸的结合亲和力，其中由我们的组提前制备SPI薄膜。在对接之后，根据它们的结合能量和SPI和芳族酸之间的相互作用模式来评估芳族酸形式的配体。对接结果表明在SPI和Na的相互作用期间含氮杂环部分保持完整。这项工作将有助于从可再生资源制造Na Incorporated Spi薄膜，具有显着的抗菌性能和合理的机械性能。

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