In Vitro Study of Degradation Behavior, Cytotoxicity, and Cell Adhesion of the Atactic Polylactic Acid for Biomedical Purposes

Morozov Alexander G.; Razborov Danila A.; Egiazaryan Tatevik A.; Batenkin Maxim A.; Aleynik Diana Ya.; Egorikhina Marfa N.; Rubtsova Yulia P.; Charikova Irina N.; Chesnokov Sergei A.; Fedushkin Igor L.

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In Vitro Study of Degradation Behavior, Cytotoxicity, and Cell Adhesion of the Atactic Polylactic Acid for Biomedical Purposes

机译：用于生物医学目的的恶劣行为，细胞毒性和细胞粘附的体外研究

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An atactic poly-d,l-lactide (PLA) is obtained via ring-opening polymerization (ROP) of lactide stereoisomers mixture catalyzed by the magnesium and calcium acenaphthylenebisamido complexes. The polymer is characterized by gel-permeation chromatography, NMR spectroscopy, and mass spectrometry. The hydrolytic degradation behavior, cytotoxicity, and cell adhesion of the resulting PLA are evaluated. The polymer degrades in phosphate-buffered saline, releasing water-soluble low molecular products that significantly influence dermal fibroblast growth. Polymer demonstrates no cytotoxicity that, along with cell adhesion and their high proliferative activity toward the PLA obtained, proves its biocompatibility.

机译：通过由镁和钙酰基吡啶基胺配合物催化的丙交酯立体异构体混合物的开环聚合（ROP）获得attactic poly-d，L-丙交酯（PLA）。聚合物的特征在于凝胶渗透色谱，NMR光谱和质谱。评价了所得PLA的水解降解行为，细胞毒性和细胞粘附。聚合物在磷酸盐缓冲的盐水中劣化，释放出显着影响皮肤成纤维细胞生长的水溶性低分子酯。聚合物表明，没有细胞毒性，随着细胞粘附和它们的高增殖活性朝向所获得的PLA，证明其生物相容性。

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来源
《Journal of Polymers and the Environment》 |2020年第10期|2652-2660|共9页
作者
Morozov Alexander G.; Razborov Danila A.; Egiazaryan Tatevik A.; Batenkin Maxim A.; Aleynik Diana Ya.; Egorikhina Marfa N.; Rubtsova Yulia P.; Charikova Irina N.; Chesnokov Sergei A.; Fedushkin Igor L.;
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作者单位

Russian Acad Sci GA Razuvaev Inst Organometall Chem Nizhnii Novgorod 603950 Russia;

Russian Acad Sci GA Razuvaev Inst Organometall Chem Nizhnii Novgorod 603950 Russia;

Russian Acad Sci GA Razuvaev Inst Organometall Chem Nizhnii Novgorod 603950 Russia;

Russian Acad Sci GA Razuvaev Inst Organometall Chem Nizhnii Novgorod 603950 Russia;

Privolzhsky Res Med Univ Minist Hlth Care Russian Federat Nizhnii Novgorod 603005 Russia;

Privolzhsky Res Med Univ Minist Hlth Care Russian Federat Nizhnii Novgorod 603005 Russia;

Privolzhsky Res Med Univ Minist Hlth Care Russian Federat Nizhnii Novgorod 603005 Russia;

Privolzhsky Res Med Univ Minist Hlth Care Russian Federat Nizhnii Novgorod 603005 Russia;

Russian Acad Sci GA Razuvaev Inst Organometall Chem Nizhnii Novgorod 603950 Russia;

Russian Acad Sci GA Razuvaev Inst Organometall Chem Nizhnii Novgorod 603950 Russia;

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正文语种 eng
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关键词
Lactide; Ring-opening polymerization; Alkali-earth metal complexes; Polylactic acid; Hydrolytic degradation; Cytotoxicity; Cell adhesion; Biocompatibility;

机译：丙交酯;开环聚合;碱土金属配合物;聚乳酸;水解降解;细胞毒性;细胞粘附;生物相容性;

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In Vitro Study of Degradation Behavior, Cytotoxicity, and Cell Adhesion of the Atactic Polylactic Acid for Biomedical Purposes

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