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首页> 外文期刊>Journal of Polymers and the Environment >Block Copolymers of Poly(ε-caprolactone) with pH-Responsive Side-Chain Amino Acid Moieties
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Block Copolymers of Poly(ε-caprolactone) with pH-Responsive Side-Chain Amino Acid Moieties

机译：用pH响应侧链氨基酸部分嵌段聚（ε-己内酯）的共聚物

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摘要

To prepare amphiphilic block copolymers consisting of biocompatible and biodegradable segments, herein we report synthesis of diblock copolymers having epsilon-caprolactone (epsilon-CL) repeating units in one block and amino acid-based acrylate monomers in another segment. The block copolymers were prepared by a combination of metal-free ring-opening polymerization (ROP) of epsilon-CL and reversible addition-fragmentation chain transfer (RAFT) polymerization oftert-butyloxycarbonyl (Boc)-alanine/Boc-leucine based acrylate monomers. The ROP of epsilon-CL was initiated with diphenyl phosphate (DPP) as a metal-free catalyst in conjunction with a heterofunctional initiator, benzyl-2-hydroxyethyl carbonotrithioate, produced trithiocarbonate terminated poly(epsilon-caprolactone) (PCL). This was further employed as macro-chain transfer agent for the synthesis of side chain amino acid containing blockviaRAFT. Deprotection of Boc group pendants from the block copolymers under acidic conditions at room temperature provided pH responsive block copolymers with positively charged cationic primary amine functionalities. Furthermore, self-assembling nature of these block copolymers in aqueous medium was examined through dynamic light scattering (DLS) and field emission-scanning electron microscopy (FE-SEM). Graphic
机译：为了制备由生物相容性和可生物降解的段组成的两亲嵌段共聚物，本文报告了在另一种区段中的一种嵌段和氨基酸基丙烯酸酯单体中具有ε-己内酯（EPSILON-CL）重复单元的二嵌段共聚物的合成。通过Epsilon-Cl和可逆添加 - 碎裂链转移（RAFT）聚合的无金属开环聚合（ROP）的组合来制备嵌段共聚物，并替换 - 丁氧基羰基（BOC） - 氨基/ Boc-亮氨酸基丙烯酸酯单体。与异官能引发剂，苄基-2-羟乙基碳化氢噻嗪，产生的三碳酸酯终止聚（ε-己内酯）（PCL），用二苯基-ClOx（DPP）作为无金属引发剂的催化剂，作为无金属催化剂引发。这进一步用作含有嵌粒植物的侧链氨基酸的宏链转移剂。在室温下在酸性条件下从嵌段共聚物中脱保护来自嵌段共聚物，提供了具有带正电荷的阳离子伯胺官能团的pH响应嵌段共聚物。此外，通过动态光散射（DLS）和现场发射扫描电子显微镜（Fe-SEM）检查这些嵌段共聚物中的这些嵌段共聚物的自组装性质。形象的

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