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首页> 外文期刊>Journal of Polymers and the Environment >Improved Chemosensitization Activity of Carboxymethyl Chitosan/PVA Hydrogels by Plasma Surface Modification
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Improved Chemosensitization Activity of Carboxymethyl Chitosan/PVA Hydrogels by Plasma Surface Modification

机译：通过等离子体表面改性改善羧甲基壳聚糖/ PVA水凝胶的化学敏化活性

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摘要

As global population escalates; the need for better healthcare shall inevitably intensify. Current scenario, thus, calls for a versatile technology for the construction for smart biomaterials to cater to the needs. In this context; hydrogels comprising carboxymethyl chitosan and polyvinyl alcohol (CMCS/ PVA) were fabricated using a green crosslinker, tetraethyl orthosilicate. To enhance their bio-efficacy; cold plasma assisted surface tailoring of the aforesaid hydrogels was performed as a function of four different gases viz Air, Ar, He and N-2. Apart from improving the surface wettability; plasma treatment endowed the hydrogels with an improved tensile strength. 5-Fluorouracil (5FU) release studies from the hydrogels validated their potential as oral colon-targeted delivery systems. Hemolytic experiments revealed no adverse effect on RBCs post-plasma treatment. Pristine hydrogels exhibited good cytocompatibility with MCF-7 cells. A strong cell growth inhibition was observed from 5FU-loaded hydrogels as validated by caspase-3 assay. Further assessment by the soil burial test revealed the hydrogels were biodegradable. Among all, the Ar-plasma treated hydrogel demonstrated superior hemocompatibility, chemosensitivity and biodegradability. Thus, cold plasma technology has invariably paved the path as an eco-friendly, economical and effectual strategy for development of novel CMCS/ PVA hydrogels in anticancer therapy.
机译：随着全球人口升级;对更好的医疗保健的需求不可避免地加剧。因此，目前的情景呼吁为智能生物材料构建提供多功能技术，以满足需求。在这种情况下;使用绿色交联剂，四乙基硅酸盐制备包含羧甲基壳聚糖和聚乙烯醇（CMCS / PVA）的水凝胶。提高他们的生物疗效;上述水凝胶的冷等离子体辅助表面剪裁为四种不同的气体，AR，He和N-2的函数。除了改善表面润湿性;等离子体处理具有改善的拉伸强度的水凝胶。 5-氟尿嘧啶（5FU）水凝胶的释放研究验证了它们作为口服结肠靶向递送系统的潜力。溶血实验表明对血浆后血浆治疗的不良影响。原始水凝胶与MCF-7细胞表现出良好的细胞粘合性。从Caspase-3测定验证的5Fu加载的水凝胶中观察到强细胞生长抑制。土壤埋葬测试进一步评估显示水凝胶是可生物降解的。其中，Ar - 血浆处理的水凝胶显示出优异的血液化，化学敏感性和生物降解性。因此，冷等离子体技术总是铺设了这条道路，作为一种环保，经济，有效的抗癌治疗中的新型CMC / PVA水凝胶的策略。

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