• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Polymers and the Environment >Investigation of pH-Sensitive Swelling and Curcumin Release Behavior of Chitglc Hydrogel
【24h】

Investigation of pH-Sensitive Swelling and Curcumin Release Behavior of Chitglc Hydrogel

机译：Chitglc水凝胶的pH敏感性膨胀和姜黄素释放行为的研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hydrogels are in use for encapsulation of curcumin for possible use in wound healing. Encapsulation helps in targeted delivery and enhanced activity of curcumin. We report here a pH sensitive hydrogel developed from chitosan. The hydrogel was prepared by reaction of chitosan and d-glucose, facilitated by the reducing agent Na-cyanoborohydride. The maximum yield of the hydrogel was obtained at pH 4.5 with the amount of chitosan, d-glucose and Na-cyanoborohydride as 0.3, 2.0 and 2.0 g respectively. A maximum curcumin loading efficiency of 74% was observed with curcumin amount in the feed at 0.15 g. The release study revealed a sustained release pattern over a period of 80 h with an initial burst release. Curcumin loaded hydrogel showed mild antibacterial activity against Proteus mirabilis and Enterobacter aerogenes.
机译：水凝胶用于封装姜黄素，可能用于伤口愈合。封装有助于姜黄素的靶向递送和增强的活性。我们在这里报告了从壳聚糖开发的pH敏感水凝胶。通过壳聚糖和d-葡萄糖的反应在还原剂Na-氰基硼氢化物的促进下制备水凝胶。在pH 4.5的条件下，壳聚糖，d-葡萄糖和Na-氰基硼氢化物的量分别为0.3 g，2.0 g和2.0 g，可获得水凝胶的最大产量。饲料中的姜黄素含量为0.15 g时，观察到最大姜黄素负载效率为74％。释放研究表明，在最初的突然释放下，持续80 h的持续释放模式。姜黄素负载的水凝胶显示出对奇异变形杆菌和产气肠杆菌的温和抗菌活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号