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首页> 外文期刊>Journal of porous materials >Rational synthesis of magnetic Fe_3O_4@MOF nanoparticles for sustained drug delivery
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Rational synthesis of magnetic Fe_3O_4@MOF nanoparticles for sustained drug delivery

机译：磁Fe_3O_4 @ MOF纳米颗粒的合理合成

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Drug delivery carrier for targeted and controlled drug release is very important but challenging. In this work, a nano-sized metal-organic frameworks (MOFs)-based magnetic core-shell nanoparticles (NPs) has been designed for targeted drug delivery. Fe3O4@MIL-100(Fe) magnetic NPs were successfully prepared by a facile step-by-step assembly method. By the combination of the high porosity of MOFs shell and the magnetic characteristics of Fe3O4 core, making Fe3O4@MIL-100(Fe) magnetic NPs as an excellent drug delivery system. Significantly, the anti-inflammatory drug Ibuprofen (IBU) was effectively loaded on the magnetic NPs with a loading capacity of 0.31gg(-1), and it took as long as 70h to release IBU completely in PBS buffer solution at 37 degrees C. This work demonstrates that the nano-sized MOFs-based magnetic NPs are promising candidates for targeted drug delivery applications.
机译：针对靶向和控制的药物释放的药物递送载体非常重要但挑战性。在这项工作中，为靶向药物递送设计了一种基于纳米金属 - 有机框架（MOF）的磁芯 - 壳纳米粒子（NPS）。 FE3O4 @ MIL-100（FE）磁NPS通过容易逐步的组装方法成功制备。通过MOF壳的高孔隙率和Fe3O4核的磁特性，使Fe3O4 @ MIL-100（Fe）磁NPS作为优异的药物递送系统。显着地，抗炎药布洛芬（IBU）有效地装载在磁NP上，其负载能力为0.31gg（-1），并且只需在37℃下完全在PBS缓冲溶液中完全释放IBU即可。这项工作表明，纳米大小的基于MOFS的磁NPS是针对目标药物递送应用的承诺候选者。

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