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首页> 外文期刊>The Journal of the Textile Institute >PVA nanofibers containing ofloxacin/α-cyclodextrin inclusion complexes: improve ofloxacin water solubility
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PVA nanofibers containing ofloxacin/α-cyclodextrin inclusion complexes: improve ofloxacin water solubility

机译：含有氧氟沙星/α-环糊精包合复合物的PVA纳米纤维：改善氧氟沙星水溶性

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摘要

Abstract Ofloxacin (OFL) is an antibiotic with a wide range of bacterial infections but its low water solubility and photo stability restricts its applications, so improve its solubility and stability is a challenge. Inclusion complex formation between α-cyclodextrin (α-CD) and OFL was prepared under various circumstances to obtained desirable water solubility. The effect of polyethylene glycol physiologically compatible solubilizing agent and mixing condition were investigated in the formation of an inclusion complex between α-CD/OFL. FTIR, H-NMR, DSC and XRD results indicated the formation of an inclusion complex between α-CD/OFL. Phase solubility test for obtaining α-CD/OFL complexes indicated a rise in aqueous solubility of OFL and formation of inclusion complexes and obviating OFL aqueous solubility limitation. SEM and EDX results indicated OFL/CD/PVA nanofibers without beading defect. Antibacterial activities of OFL/CD nanoparticles were investigated by them inhabitation of bacteria growth. Obtained nanofibers showed significant antibacterial effect against Escherichia Coli and Staphylococcus aureus.
机译：摘要氧氟沙星（OFL）是一种抗生素，具有广泛的细菌感染，但其低水溶性和光稳定性限制了其应用，因此提高其溶解性和稳定性是挑战。在各种情况下制备α-环糊精（α-CD）和OF1之间的包含复合物形成，以获得所需的水溶性。研究了聚乙二醇生理相容的增溶剂和混合条件的影响在α-CD / OF1之间的形成复合物中。 FTIR，H-NMR，DSC和XRD结果表明在α-CD / OF1之间形成包含复合物。用于获得α-CD / OF1络合物的相溶解度试验表明OF1的水溶性和包合物的形成升高，并避免了含水溶解度限制。 SEM和EDX结果表明OF / CD / PVA纳米纤维没有珠缺损。通过鉴于细菌生长研究了OFL / CD纳米粒子的抗菌活性。获得的纳米纤维显示出对大肠杆菌和金黄色葡萄球菌的显着抗菌作用。

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