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首页> 外文期刊>The Journal of the Textile Institute >Fabrication, characterization and drug release behaviors of chitosan microfibers loaded with herbal or non-herbal drugs
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Fabrication, characterization and drug release behaviors of chitosan microfibers loaded with herbal or non-herbal drugs

机译：壳聚糖微纤维装载草药或非草药的制备，表征和药物释放行为

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摘要

Two chitosan, CS, microfibers loaded with the herbal persimmon leaves, PL, and the non-herbal metformin hydrochloride, MH, were wet spun, respectively. SEM images shown that these two CS microfibers have different surface morphologies at the as-spun state due to the PL-loaded fiber presented the squamae-like structure and the MH-loaded fiber presented some bright dots. This suggested that the PL and MH were loaded in the CS chains by different mechanisms and some loaded MH molecules out of the CS chains might be free and separated by spinning-induced extrusion forces. FTIR spectra analysis indicated that the PL was loaded in the CS chains mainly by the O-H groups and formed the interpenetration network and the MH was loaded in the CS chains mainly by the N-H groups and formed the sheathing structure. The loading of these herbal and non-herbal drugs in CS chains both shown good miscibility while the mechanical properties were reduced as compared with the pure CS fiber. The release of the PL and MH from CS fibers both followed the same Langmuir kinetics model, while the comparisons found that the released amount was greater for the PL and the release rate was faster for the MH.
机译：两个壳聚糖，CS，微纤维装有中草药柿叶，PL，以及非草药盐酸二甲双胍，MH，进行湿纺，分别。示出的SEM图像，这两种微纤维CS在初纺状态由于PL-加载纤维具有不同的表面形貌所呈现的鳞片状结构和MH-加载的纤维呈现一些亮点。这表明，在PL和MH在CS链通过不同的机制和一些加载MH分子进行的CS链可能是免费的，并通过旋转引起的挤压力分开加载。 FTIR光谱分析表明，PL是在CS链加载主要通过O-H基团和形成的互穿网络和MH是在CS链加载主要由N-H基团和形成在所述护套的结构。这些草药和非草药在CS链装载均示良好的混溶性，而机械特性降低与纯CS纤维相比。 P1和MH从CS纤维的释放都遵循同样的朗缪尔动力学模型，而比较发现，对于PL释放量更大了，释放速率为MH更快。

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