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首页> 外文期刊>The Journal of the Textile Institute >Study on release of cardamom extract as an antibacterial agent from electrospun scaffold based on sodium alginate
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Study on release of cardamom extract as an antibacterial agent from electrospun scaffold based on sodium alginate

机译：基于藻酸钠的Electur纺支架释放豆蔻提取物作为抗菌剂的研究

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In the present study, sodium alginate (SA):polyvinyl alcohol(PVA) blends with different concentrations of cardamom extract (CE) were electrospun. The SEM images show that the optimum content of CE was 10 wt% resulting in fibers with average diameter of 233 +/- 33 nm. FTIR spectra was employed to investigate probable interactions between polymers and CE. The CE release follows first order kinetics with 86% initial burst release at the first 24 h necessary to desired antibacterial activity. To investigate the biological properties, MTT assay, cell adhesion and antibacterial test were carried out. The SA:PVA:CE nanofibers showed no toxicity against fibroblast cells. The cell culture results exhibited the proper biocompatibility and proliferation on both CE-loaded and unloaded webs. The antibacterial test showed that CE-loaded nanofibrous web is capable of improving the antibacterial activity about 99% and 97% against gram-positive and gram-negative bacteria, respectively. Therefore, the CE-loaded web can be used as an antimicrobial wound dressing for healing improvement.
机译：在本研究中，藻酸钠（SA）：具有不同浓度的豆蔻果实提取物（CE）的聚乙烯醇（PVA）是Electrom ow。 SEM图像表明CE的最佳含量为10wt％，导致平均直径为233 +/- 33nm的纤维。使用FTIR光谱来研究聚合物和Ce之间的可能相互作用。 CE释放遵循第一定的动力学，在所需的前24小时内具有86％的初始突发释放，以到所需的抗菌活性。为了研究生物学性质，进行MTT测定，细胞粘附和抗菌试验。 SA：PVA：Ce纳米纤维对成纤维细胞没有毒性。细胞培养结果表现出CE加载和卸载腹板上的适当生物相容性和增殖。抗菌试验表明，Ce负载的纳米纤维网能够分别改善抗菌活性，分别提高抗菌活性约99％和97％抗革兰氏阳性和革兰氏阴性细菌。因此，Ce加载的网可以用作抗微生物伤口敷料以愈合改善。

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