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首页> 外文期刊>The Journal of the Textile Institute >A comparative computational study of blood flow pattern in exemplary textile vascular grafts
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A comparative computational study of blood flow pattern in exemplary textile vascular grafts

机译：典型纺织血管移植物中血流模式的比较计算研究

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摘要

Textile vascular grafts are biomedical devices and play an important role serving as a solution for the partial replacement of damaged arterial vessels. It is believed that the success of a textile vascular graft, in the healing process after implantation, is due to the porous micro-structure of the wall. Although the transport of fluids through textiles is of great technical interest in biomedical applications, little is known about predicting the micro-flow pattern and cellular transport through the wall. The aim of this work is to investigate how the type of fabric, permeability and porosity affect both the local fluid dynamics at several scales and the fluid-particle interaction between platelets in textile grafts, related with the graft occlusion. This study involves both experimental and computational tests. Experimental tests are performed to characterize the permeability and porosity according to the ISO 7198 standard. The numerical process is based on a multi-scale approach where the fluid flow is solved with the Finite Element Method and the discrete particles are solved with the Molecular Dynamic Method. The results have shown that the type of fabric in textile vascular grafts and the degree of porosity and permeability affect both the local fluid dynamics and the level of penetration of platelets through the wall, thus indicating their importance as design parameters.
机译：纺织血管移植物是生物医学装置，并在解决受损动脉血管的部分替换方面起着重要作用。可以相信，在植入后的愈合过程中，纺织血管移植物的成功归因于壁的多孔微结构。尽管流体通过纺织品的运输在生物医学应用中具有重大的技术意义，但对于预测微流模式和细胞通过壁的运输知之甚少。这项工作的目的是研究织物的类型，渗透性和孔隙率如何在几个尺度上影响局部流体动力学以及纺织品嫁接物中血小板之间的流体-颗粒相互作用，并与嫁接闭塞相关。这项研究涉及实验和计算测试。根据ISO 7198标准进行了实验测试，以表征渗透率和孔隙率。数值过程是基于多尺度方法的，其中使用有限元方法求解流体流动，并使用分子动力学方法求解离散颗粒。结果表明，纺织血管移植物中的织物类型以及孔隙度和渗透性的程度会影响局部流体动力学和血小板穿过壁的渗透程度，因此表明它们作为设计参数的重要性。

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