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首页> 外文期刊>The Journal of the Textile Institute >NiO-/cotton-modified nanocomposite as a medication model for bacterial-related burn infections
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NiO-/cotton-modified nanocomposite as a medication model for bacterial-related burn infections

机译：NiO /棉改性的纳米复合材料作为细菌相关烧伤感染的药物模型

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摘要

Burn injuries are one of the major global health problems. Despite aggressive local and systemic treatment to minimize infection, severe burn wounds continue to become infected with environmental and nosocomial pathogens at relatively high rates. We developed an ultrasound assisted sol-gel technique to prepare treated cotton fibers by coating fabric surface with NiO/organic polymer/enzyme matrix for in vitro evaluation of antibacterial activity. The surface modification was performed to bond more efficiently NiO nanoparticles using cellulase enzyme, to reduce initial bacterial attachment on the hydrophilic surface using poly(ethylene glycol), and to promote ultrasonic generation and to overcome agglomeration of the nanoparticles, respectively. Disk diffusion method was used to quantify the efficacy of NiO-based cottons against Pseudomonas aeruginosa and Staphylococcus aureus as two most burn wound pathogens isolated from burn wound swabs and tissue biopsies of hospitalized burn patients. Almost bacterial isolates showed high resistance to the commonly used antibiotics for burn infection treatment. In vitro antibacterial evaluation showed that the modified cottons exhibited excellent biocidal action against both high-resistant isolated Gram-positive and Gram-negative bacteria.
机译：烧伤是全球主要的健康问题之一。尽管积极地进行了局部和全身治疗以最小化感染，但严重的烧伤创面仍以较高的比率感染了环境和医院病原体。我们开发了超声辅助溶胶凝胶技术，通过在织物表面覆盖NiO /有机聚合物/酶基质来制备经处理的棉纤维，以进行体外抗菌活性评估。进行表面改性以使用纤维素酶更有效地键合NiO纳米颗粒，使用聚乙二醇减少亲水性表面上的初始细菌附着，并促进超声的产生并克服纳米颗粒的团聚。圆盘扩散法用于量化NiO基棉花对铜绿假单胞菌和金黄色葡萄球菌作为两种烧伤创面病原体的功效，这两种病原体是从烧伤拭子和住院烧伤患者的组织活检物中分离得到的。几乎细菌分离株对烧伤感染治疗常用抗生素表现出很高的抵抗力。体外抗菌评估表明，改性棉对高抗性革兰氏阳性菌和革兰氏阴性菌均表现出优异的杀菌作用。

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