...
首页> 外文期刊>Journal of the American Chemical Society >Pillar[6]arene/Paraquat Molecular Recognition in Water: High Binding Strength, pH-Responsiveness, and Application in Controllable Self-Assembly, Controlled Release, and Treatment of Paraquat Poisoning
【24h】

Pillar[6]arene/Paraquat Molecular Recognition in Water: High Binding Strength, pH-Responsiveness, and Application in Controllable Self-Assembly, Controlled Release, and Treatment of Paraquat Poisoning

机译:水中的柱子[6]芳烃/百草枯分子识别:高结合强度,pH响应性及其在可控自组装,控释和百草枯中毒中的应用

获取原文
获取原文并翻译 | 示例
           

摘要

The complexation between a water-soluble pillar[6]arene (WP6) and paraquat (Gl) in water was investigated. They could form a stable 1:1 [2]pseudorotaxane with an extremely high association constant of (1.02 ± 0.10) × 10~8 M~(-1) mainly driven by electrostatic interactions, hydrophobic interactions, and π—π stacking interactions. This molecular recognition has not only high binding strength but also pH- responsiveness. The threading and dethreading processes of this [2]pseudorotaxane could be reversibly controlled by changing the solution pH. This novel recognition motif was further used to control the aggregation of a complex between WP6 and an amphiphilic paraquat derivative (G2) in water. The reversible transformations between micelles based on G2 and vesicles based on WP6つG2 were realized by adjusting the solution pH due to the pH-responsiveness of WP6. The controlled release of water-soluble dye molecules from the vesicles could be achieved by the collapse of the vesicles into the micelles upon changing the solution pH to acidity. Additionally, the high binding affinity between WP6 and paraquat could be utilized to efficiently reduce the toxitity of paraquat. After the formation of a stable host-guest complex between WP6 and paraquat, less opportunity was available for paraquat to interact with the reducing agents in the cell, which made the generation of its radical cation more difficult, resulting in the efficient reduction of paraquat toxicity.
机译:研究了水溶性支柱[6]芳烃(WP6)和百草枯(G1)在水中的络合作用。它们可以形成稳定的1:1 [2]假轮烷,具有极高的缔合常数(1.02±0.10)×10〜8 M〜(-1),主要由静电相互作用,疏水相互作用和π-π堆积相互作用驱动。这种分子识别不仅具有高结合强度,而且具有pH响应性。可以通过改变溶液的pH值来可逆地控制[2]假轮烷的穿线和脱线过程。该新颖的识别基序还用于控制WP6与两亲百草枯衍生物(G2)在水中的复合物的聚集。由于WP6的pH响应性,通过调节溶液的pH值可以实现基于G2的胶束和基于WP6つG2的囊泡之间的可逆转化。通过将溶液的pH值改变为酸性,使囊泡塌陷进入胶束中,可以实现水溶性染料分子从囊泡的受控释放。另外,可利用WP6和百草枯之间的高结合亲和力来有效降低百草枯的毒性。在WP6和百草枯之间形成稳定的宿主-客体复合物后,百草枯与细胞中的还原剂相互作用的机会较少,这使其自由基阳离子的产生更加困难,从而有效降低了百草枯的毒性。

著录项

  • 来源
    《Journal of the American Chemical Society》 |2012年第47期|19489-19497|共9页
  • 作者单位

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Chemistry, Zhejiang University,Hangzhou 310027, P. R China;

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering,Zhejiang University, Hangzhou 310027, P. R China;

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Chemistry, Zhejiang University,Hangzhou 310027, P. R China;

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Chemistry, Zhejiang University,Hangzhou 310027, P. R China;

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering,Zhejiang University, Hangzhou 310027, P. R China;

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering,Zhejiang University, Hangzhou 310027, P. R China;

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Chemistry, Zhejiang University,Hangzhou 310027, P. R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号