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Size dependent correlation between structure and apparent stiffness of viral DNA during temperature variation

机译：温度变化期间病毒DNA结构与表观刚度之间的大小相关性相关性

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摘要

Nucleic acid is indispensable to most viruses, and its mechanical property is an important factor for virus infectivity. Recent experiments found a temperature dependence of viral apparent stiffness, which stirred up controversy if apparent stiffness variation was ascribed to temperature-dependent structure variation of viral DNA. This paper is aimed to clarify this controversy by exploring the mechanism in apparent stiffness variation of viral DNA. A multi-scale correlation between microscopic structure of viral DNA and its apparent stiffness is formulated by presenting an alternative mesoscopic free energy model of viral DNA with the inclusion of its two-domain structural feature. Results reveal that the increasing temperature promotes DNA structural transformation from order to disorder, larger viral size will induce more dramatic DNA structural transformation, and this size-dependent temperature effect of viral DNA structure leads to cor-responding change of its free energy and apparent stiffness. These temperature-induced changes in DNA structure, energy, stiffness are reflection of competition between microscopic interactions of ordered and disordered DNA domains, and the ordered DNA domain dominates the changes of general viral DNA structure and energy. The results can provide insights into potential methods to prevent viral infection disease or to regulate gene delivery.
机译：核酸对大多数病毒是必不可少的，其力学性质是病毒感染性的重要因素。最近的实验发现病毒表观刚度的温度依赖性，如果表观刚度变化归因于病毒DNA的温度依赖性结构变异，则搅拌争议。本文旨在通过探索病毒DNA表观刚度变异的机制来阐明这一争议。通过呈现其双结构域结构特征，通过呈现病毒DNA的替代型介观可用能量模型来配制病毒DNA微观结构与其表观刚度的多尺度相关性。结果表明，越来越多的温度促进从紊乱到紊乱的DNA结构转化，较大的病毒大小将诱导更显着的DNA结构转化，并且病毒DNA结构的这种尺寸依赖性温度效应导致其自由能和表观刚度的响应变化。这些温度诱导的DNA结构变化，能量，刚度是有序和无序DNA结构域的显微静脉间相互作用之间的竞争的反映，并且有序的DNA结构域主导了一般病毒DNA结构和能量的变化。结果可以为预防病毒感染疾病或调节基因递送的潜在方法提供见解。

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  • 来源
    《Journal of the Mechanics and Physics of Solids》 |2021年第9期|104501.1-104501.18|共18页
  • 作者

    Cheng-Yin Zhang; Neng-Hui Zhang;

  • 作者单位

    Department of Mechanics School of Mechanics and Engineering Science Shanghai University Shanghai 200444 China;

    Department of Mechanics School of Mechanics and Engineering Science Shanghai University Shanghai 200444 China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Viral mechanics; Temperature dependence; Two-domain structure; Energy model; Size effect;

    机译：病毒力学;温度依赖;双域结构;能源模型;尺寸效果;

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