Polymorphic Variants of UGT1A1 in Neonatal Jaundice in Southern Brazil

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Polymorphic Variants of UGT1A1 in Neonatal Jaundice in Southern Brazil

机译：UGT1A1在巴西南部新生儿黄疸的多态性变异。

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Alterations in the hepatic conjugation of bilirubin due to uridyl-diphosphate-glucuronosyltransferase 1A1 (UGT1A1) polymorphisms have been proposed as risk factors to neonatal jaundice. Herein, we estimated the frequency of genotypes of the promoter region of UGT1A1 gene in newborns and evaluated its association with severe hyperbilirubinemia. Prospective study of cases and controls including all newborns admitted for phototherapy at HCPA, Brazil, during 9 months; 490 babies were enrolled and PCR was performed. Polymorphic genotypes were detected in 16% of the patients and 7 of the 10 possible genotypes were identified with higher prevalence of polymorphisms in Afro-descendants. In this sample, the variants of UGT1A1 were not associated to severe hyperbilirubinemia; other genic factors should be sought in this high miscegenation area of Brazil.

机译：已提出由于尿苷二磷酸-葡萄糖醛酸转移酶1A1（UGT1A1）多态性引起的胆红素肝结合改变是新生儿黄疸的危险因素。在这里，我们估计了新生儿UGT1A1基因启动子区域的基因型频率，并评估了其与严重高胆红素血症的关系。对病例和对照进行前瞻性研究，包括在9个月内在巴西HCPA接受光疗的所有新生儿；招募了490名婴儿，并进行了PCR。在16％的患者中检测到多态性基因型，在10个可能的基因型中，有7种在非洲裔中被发现具有较高的多态性。在该样本中，UGT1A1的变体与严重的高胆红素血症无关。在巴西这个高度致突变的地区应寻找其他遗传因素。

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《Journal of Tropical Pediatrics》 |2010年第5期|p.366-367|共2页
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1. Polymorphic variants of UGT1A1 in neonatal jaundice in southern Brazil. [J] . Carvalho CG, Castro SM, Santin AP, Journal of tropical pediatrics. . 2010,第5期

机译：UGT1A1在巴西南部新生儿黄疸中的多态性变异。
2. Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice [J] . Chen Shujuan, Tukey Robert H. Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2018,第11期

机译：人源化的UGT1小鼠，UGT1A1的调节，以及肠道在新生儿高胆管血症和母乳诱导的黄疸中的作用
3. The role of UGT1A1 promoter polymorphism and exon-1 mutations in neonatal jaundice [J] . Halis Hulya, Ergin Hacer, Koseler Aylin, The journal of maternal-fetal & neonatal medicine . 2017,第19a24期

机译：UGT1A1启动子多态性和Exon-1突变在新生儿Jaundice中的作用
4. Application of Fuzzy Sets in Neonatal Pathological Jaundice [C] . Chun Yang, Haihong Hu, Zheng Yang, International Conference on Information, Cybernetics, and Computational Social Systems . 2020

机译：模糊套在新生儿病理黄疸中的应用
5. An evaluation of the rate and severity of readmissions for jaundice or dehydration associated with shorter neonatal hospital stay. [D] . Lee, Kyong-Soon. 1995

机译：黄疸或脱水与新生儿住院时间短相关的再入院率和严重程度的评估。
6. Humanized UGT1 Mice Regulation of UGT1A1 and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice [O] . Shujuan Chen, Robert H. Tukey -1

机译：人源化UGT1小鼠UGT1A1的调控以及肠道在新生儿高胆红素血症和母乳引起的黄疸中的作用
7. Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice [O] . Shujuan Chen, Robert H. Tukey 2018

机译：人源化UGT1小鼠，UGT1A1的调节，以及肠道在新生儿高胆管血症和母乳诱导的黄疸中的作用

Polymorphic Variants of UGT1A1 in Neonatal Jaundice in Southern Brazil

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