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首页> 外文期刊>Journal of University of Kuwait >The effect of denervation and immobilization on the hindlimb muscles of the jerboa (Jaculus jaculus)
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The effect of denervation and immobilization on the hindlimb muscles of the jerboa (Jaculus jaculus)

机译：失神经和固定化对杰尔波亚（Jaculus jaculus）后肢肌肉的影响

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摘要

Among the different factors that influence the skeletal muscle properties and atrophic state are contractile activity and muscle neural supply. Accordingly the effects of denervation and immobilization have been studied on the extensor digitorum longus (EDL) and soleus muscle of the hindlimb of the jerboa (Jaculus jaculus). Muscle weight, total fiber number, number of different fiber types and fiber diameters of the two muscles were measured. The EDL and soleus muscles of denervated and immobilized animals were compared with those of controls. Both denervated EDL and soleus muscles showed more reduction in weight compared with immobilized muscles and controls. Following denervation, the reduction in the diameters of type ⅡB fibers in the EDL was more than that of type HA fibers, which indicated that type ⅡB fibers are in greater need of neural control than type ⅡA fibers. The degree of atrophy in type ⅡA and ⅡB fibers was more extensive after denervation than after immobilization. Type Ⅰ fibers comprising the soleus muscle were also significantly reduced in diameter after denervation. Similarly, type Ⅰ fibers in the soleus muscle were reduced in diameter more after denervation than after immobilization. The above results demonstrated that both neural innervation and activity influence jerboa muscle growth and differentiation. It is proposed that Jaculus jaculus is a good animal model system for studying the effects of activity or lack of activity on mammalian skeletal muscle.
机译：影响骨骼肌特性和萎缩状态的不同因素包括收缩活动和肌肉神经供应。因此，已经研究了去神经支配和固定对长指后伸肌（EDL）和后肢比目鱼肌（Jaculus jaculus）的影响。测量了两条肌肉的肌肉重量，总纤维数量，不同纤维类型的数量和纤维直径。将去神经支配和固定的动物的EDL和比目鱼肌与对照组进行比较。与固定的肌肉和对照组相比，失神经的EDL和比目鱼肌均显示出更多的体重减轻。去神经后，EDL中ⅡB型纤维的直径减小量大于HA型纤维的减小量，这表明ⅡB型纤维比ⅡA型纤维更需要神经控制。失神经后的ⅡA和ⅡB型纤维的萎缩程度比固定后的更为严重。去神经后，构成比目鱼肌的Ⅰ型纤维直径也明显减小。同样，比目鱼肌固定后比目鱼肌中的Ⅰ型纤维直径减小更多。以上结果证明神经支配和活动都影响到了杰波亚肌肉的生长和分化。提出Jaculus jaculus是研究活动或缺乏活动对哺乳动物骨骼肌影响的良好动物模型系统。

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