Release of Growth Factors from Gelatin Microsphere/CaP Composites

W.J.E.M. Habraken; O.C. Boerman; J.G.C. Wolke; A.G. Mikos; J.A. Jansen

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Release of Growth Factors from Gelatin Microsphere/CaP Composites

机译：明胶微球/ CaP复合材料释放生长因子

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Composites of gelatin microspheres and injectable calcium phosphate cement were prepared to increase cement resorption and improve tissue ingrowth. To further enhance these properties, osteoinductive growth factors can be introduced into the microspheres. In this study, the in vitro release of preset gelatin microsphere/CaP composites was followed for 6 weeks by use of ~(125)I-labelled rhBMP-2, rhTGF-β and rh-bFGF. Results for all gelatin microsphere composites showed a release curve that consisted of a small burst, followed by a sustained release. The magnitude of the sustained release was dependent on the growth factor used, and showed a slight dependency on the loading method and type of gelatin. Furthermore, no differences in release pattern or efficiency were found when growth factor concentration increased.

机译：制备明胶微球和可注射磷酸钙水泥的复合材料，以增加水泥吸收并改善组织向内生长。为了进一步增强这些特性，可以将骨诱导生长因子引入微球。在这项研究中，通过使用〜（125）I标记的rhBMP-2，rhTGF-β和rh-bFGF，在体外释放预设的明胶微球/ CaP复合材料6周。所有明胶微球复合材料的结果均显示出释放曲线，该曲线由小的破裂和随后的持续释放组成。持续释放的程度取决于所使用的生长因子，并且显示出对负载方法和明胶类型的轻微依赖。此外，当生长因子浓度增加时，没有发现释放模式或效率的差异。

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《Key Engineering Materials》 |2008年第pt1期|p.527-530|共4页
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W.J.E.M. Habraken; O.C. Boerman; J.G.C. Wolke; A.G. Mikos; J.A. Jansen;
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2. Effects of the Controlled-Released Basic Fibroblast Growth Factor from Chitosan-Gelatin Microspheres on Human Fibroblasts Cultured on a Chitosan-Gelatin Scaffold [J] . Haifeng Liu, Hongbin Fan, Yuanlu Cui Biomacromolecules . 2007,第5期

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3. Growth Factors Released from Gelatin Hydrogel Microspheres Increase New Neurons in the Adult Mouse Brain [J] . KanakoNakaguchi, HideoJinnou, NaokoKaneko, Stem cells international . 2012,第3期

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4. Release of Growth Factors from Gelatin Microsphere/CaP Composites [C] . W.J.E.M. Habraken, O.C. Boerman, J.G.C. Wolke, Bioceramics . 2008

机译：明胶微球/ CaP复合材料释放生长因子
5. Encapsulation and controlled release of active DNA from uncrosslinked gelatin microspheres. [D] . Hardin, James Otey, IV. 2012

机译：从未交联的明胶微球中包封和控制释放活性DNA。
6. Growth Factors Released from Gelatin Hydrogel Microspheres Increase New Neurons in the Adult Mouse Brain [O] . Kanako Nakaguchi, Hideo Jinnou, Naoko Kaneko, 2012

机译：明胶水凝胶微球释放的生长因子增加成年小鼠大脑中的新神经元。
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8. Afirm Nerve Regeneration Project 1: Growth Factor Releasing Microspheres and the Effect on Peripheral Nerve Regeneration [R] . De Boer, R., Wang, H., Knight, A. M., 2008

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Release of Growth Factors from Gelatin Microsphere/CaP Composites

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