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首页> 外文期刊>Key Engineering Materials >Preparation and Characterization of Hydroxyapatite Microspheres with Hollow Core and Mesoporous Shell
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Preparation and Characterization of Hydroxyapatite Microspheres with Hollow Core and Mesoporous Shell

机译：中空壳介孔羟基磷灰石微球的制备与表征

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摘要

Hollow hydroxyapatite microspheres (H-HAMs) with controlled characteristic mesoporous structure on the shell were successfully fabricated by using core template technology and sol-gel process. The fabrication of H-HAMs mainly included three distinct steps: the preparation of core template spheres of chitin by emulsifying chitin solution in oil, the formation of core-shell composite spheres of chitin-HA/chitin after a layer of chitin/HA solution coated on the surface of chitin core templates by means of a gelling process of chitin solution with the help of water in the cores, and the harvest of H-HAMs through a special sintering procedure to remove chitin. The size and shape of H-HAMs were chiefly determined by the size and morphology of core templates. The thickness of shells was easily controlled by altering water content of the starting template particles, and the characteristic mesoporous structure on the shell was related to the proportion of chitin in the chitin/HA composite solution and the sintering temperature. H-HAMs with characteristic mesoporous architecture on the shell have many potential applications such as used as a carrier for sustained release of drugs in the therapy of hard tissue system.
机译：利用核模板技术和溶胶-凝胶工艺成功地制备了具有可控特征介孔结构的空心羟基磷灰石微球（H-HAMs）。 H-HAMs的制备主要包括三个不同的步骤：通过在油中乳化几丁质溶液制备几丁质的核心模板球，在包衣几丁质/ HA溶液后形成几丁质-HA /甲壳质的核-壳复合球。通过甲壳质溶液的胶凝过程，借助甲壳质中的水，在甲壳质核心模板的表面上进行表面修饰，并通过特殊的烧结程序收获H-HAM，以去除甲壳质。 H-HAMs的大小和形状主要取决于核心模板的大小和形态。通过改变起始模板颗粒的水含量可以容易地控制壳的厚度，并且壳上的特征性介孔结构与甲壳质/ HA复合溶液中甲壳质的比例和烧结温度有关。在外壳上具有特征性介孔结构的H-HAM具有许多潜在的应用，例如在硬组织系统的治疗中用作药物持续释放的载体。

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