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首页> 外文期刊>Lasers in Medical Science >High-power diode laser at 980 nm for the treatment of benign prostatic hyperplasia: ex vivo investigations on porcine kidneys and human cadaver prostates
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High-power diode laser at 980 nm for the treatment of benign prostatic hyperplasia: ex vivo investigations on porcine kidneys and human cadaver prostates

机译:980 nm大功率二极管激光器用于治疗前列腺增生:猪肾和人尸体前列腺的离体研究

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Diode laser systems at 980 nm have been introduced for the treatment of lower-urinary-tract-symptoms (LUTS) suggestive of benign prostatic enlargement (BPE). However, the coagulation and vaporization properties are unknown. We therefore aimed to evaluate these properties in ex vivo models in comparison with the kalium-titanyl-phosphate-(KTP) laser. The diode laser treatment was applied to isolated, blood-perfused porcine kidneys and fresh human cadaver prostates (HCPs) at different generator settings. We performed histological examination to compare the depth of coagulation and vaporization. The diode laser showed larger ablation and coagulation characteristics than the KTP laser did. Ablation of the diode laser was found to be 1.79-times (120 W in porcine kidney, P < 0.0001) and 3.0–5 times (200 W in HCP, P < 0.0005) larger. The diode laser created a nine-times (120 W in porcine kidney, P < 0.0001) and seven-times (200 W in HCP, P < 0.0001) deeper necrosis zone. The diode laser vaporization was highly effective ex vivo. Owing to the laser’s deep coagulation zones, in vivo animal experiments are mandatory before the diode laser (980 nm) is applied in a clinical setting, so that damage to underlying structures is prevented.
机译:已经引入了980 nm的二极管激光系统,用于治疗提示前列腺增生(BPE)的下尿路症状(LUTS)。然而,凝结和汽化特性是未知的。因此,我们旨在与离体的钛-磷酸钾-磷酸-(KTP)激光相比,在离体模型中评估这些特性。在不同的发生器设置下,将二极管激光治疗应用于离体的血液灌注的猪肾脏和新鲜的人尸体前列腺(HCP)。我们进行了组织学检查,以比较凝结和汽化的深度。二极管激光器显示出比KTP激光器更大的消融和凝结特性。发现二极管激光器的烧蚀大1.79倍(猪肾脏120 W,P <0.0001)和3.0-5倍(HCP中200 W,P <0.0005)。二极管激光器产生了九倍(在猪肾脏中为120 W,P <0.0001)和七倍(在HCP中为200 W,P <0.0001)更深的坏死区。二极管激光器汽化离体是非常有效的。由于激光器的深凝区,必须在临床环境中应用二极管激光器(980 nm)之前,必须进行体内动物实验,以防止损坏基础结构。

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