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Censored quantile regression for residual lifetimes

机译:剩余寿命的删失分位数回归

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We propose a regression method that studies covariate effects on the con ditional quantiles of residual lifetimes at a certain followup time point. This can be particularly useful in cancer studies, where more patients survive cancers initially and a patient's residual life expectancy is used to compare the efficacy of secondary or adjuvant therapies. The new method provides a consistent estimator that often exhibits smaller standard error in real and simulated examples, compared to the existing method of Jung et al. (2009). It also provides a simple empirical likelihood inference method that does not require estimating the covariance matrix of the estimator or resampling. We apply the new method to a breast cancer study (NSABP Protocol B-04, Fisher et al. (2002)) and estimate median residual lifetimes at various followup time points, adjusting for important prognostic factors.
机译:我们提出了一种回归方法,该方法研究在某个后续时间点上对剩余寿命的条件分位数的协变量影响。这在癌症研究中尤其有用,在该研究中,更多的患者最初在癌症中幸存下来,并且使用患者的剩余预期寿命来比较二级或辅助疗法的疗效。与Jung等人的现有方法相比,新方法提供了一个一致的估计量,该估计量在真实和模拟示例中通常表现出较小的标准误差。 (2009)。它还提供了一种简单的经验似然推断方法,该方法不需要估计估计量的协方差矩阵或重新采样。我们将这种新方法应用于乳腺癌研究(NSABP协议B-04,Fisher等人(2002年)),并根据不同的预后因素,估计了各个随访时间点的平均剩余寿命。

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