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A Continuous-Flow Polymerization Microprocess with Online GPC and Inline Polymer Recovery by Micromixer-Assisted Nanoprecipitation

机译:具有在线GPC和通过微混合器辅助的纳米沉淀进行在线聚合物回收的连续流聚合微工艺

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摘要

A microplant, starting from monomers to produce polymer particles, is described and integrates polymerization reaction, polymer analysis and nanoparticle formation in a single continuous-flow microprocess. Original contribution is brought by online polymer analysis and inline polymer nanoprecipitation. Multi-detection GPC of samples taken at the outlet of the microreactor actually enables the characterization of linear and branched polymers by combining a concentration- and a mass-sensitive detection technique. When the steady state of the micro-reactor is reached, micromixer-assisted nanoprecipitation of the polymer solution follows, leading to a colloidal suspension of nanoparticles with a narrow particle size distribution. Particle sizes, around 100 nm, can be tuned by process parameters.
机译:描述了一种从单体开始生产聚合物颗粒的微型工厂,该工厂将聚合反应,聚合物分析和纳米颗粒形成整合到一个连续的流式微工艺中。最初的贡献来自在线聚合物分析和在线聚合物纳米沉淀。通过结合浓度敏感和质量敏感的检测技术,在微反应器出口采集的样品的多检测GPC实际上可以表征线性和支链聚合物。当达到微反应器的稳态时,接着进行聚合物溶液的微混合器辅助的纳米沉淀,从而导致具有窄粒度分布的纳米粒子的胶体悬浮液。可以通过工艺参数调整大约100 nm的粒径。

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  • 来源
    《Macromolecular reaction engineering》 |2011年第12期|p.542-547|共6页
  • 作者单位

    Groupe d'Intensification et I'lntrapolation des Procedes Polymeres (G2IP), Laboratoire d'lngenierie des Polymeres pour les autes Technologies (LIPHT), EAc(CNRS) 4379, Ecole de Chimie Polymeres et Materiaux (ECPM), Universite de Strasbourg (UdS), 25 rue Becquerel, Strasbourg Cedex 2, F-67087, France;

    rnGroupe d'Intensification et I'lntrapolation des Procedes Polymeres (G2IP), Laboratoire d'lngenierie des Polymeres pour les autes Technologies (LIPHT), EAc(CNRS) 4379, Ecole de Chimie Polymeres et Materiaux (ECPM), Universite de Strasbourg (UdS), 25 rue Becquerel, Strasbourg Cedex 2, F-67087, France;

    rnLaboratoire de Chimie des Polymeres Organiques (LCPO), CNRS - ENSCPB, Universite de Bordeaux 1, 16 av. Pey-Berland, Pessac Cedex, F-33607, France;

    rnLaboratoire de Conception et Application de Molecules Bioactives, equipe de Pharmacie Biogalenique, CNRS 7199, Faculte de Pharmacie, Universite de Strasbourg (UdS), 74 route du Rhin BP 60024, Illkirch Cedex, F-67401, France;

    rnLaboratoire de Conception et Application de Molecules Bioactives, equipe de Pharmacie Biogalenique, CNRS 7199, Faculte de Pharmacie, Universite de Strasbourg (UdS), 74 route du Rhin BP 60024, Illkirch Cedex, F-67401, France;

    rnLaboratoire de Chimie des Polymeres Organiques (LCPO), CNRS - ENSCPB, Universite de Bordeaux 1, 16 av. Pey-Berland, Pessac Cedex, F-33607, France;

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