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首页> 外文期刊>Marine ecology progress series >Variations of transcript profiles between sea otters Enhydra lutris from Prince William Sound, Alaska, and clinically normal reference otters
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Variations of transcript profiles between sea otters Enhydra lutris from Prince William Sound, Alaska, and clinically normal reference otters

机译：来自阿拉斯加威廉王子湾的海獭Enhydra lutris和临床正常参考水獭之间的转录谱变化

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摘要

Development of blood leukocyte gene transcript profiles has the potential to expand condition assessments beyond those currently available to evaluate wildlife health, including sea otters Enhydra lutris, both individually and as populations. The 10 genes targeted in our study represent multiple physiological systems that play a role in immuno-modulation, inflammation, cell protection, tumor suppression, cellular stress-response, xenobiotic metabolizing enzymes, and antioxidant enzymes. These genes can be modified by biological, physical, or anthropogenic impacts and consequently provide information on the general type of stressors present in a given environment. We compared gene transcript profiles of sea otters sampled in 2008 among areas within Prince William Sound impacted to varying degrees by the 1989 'Exxon Valdez' oil spill with those of captive and wild reference sea otters. Profiles of sea otters from Prince William Sound showed elevated transcription in genes associated with tumor formation, cell death, organic exposure, inflammation, and viral exposure when compared to the reference sea otter group, indicating possible recent and chronic exposure to organic contaminants. Sea otters from historically designated oiled areas within Prince William Sound 19 yr after the oil spill had higher transcription of genes associated with tumor formation, cell death, heat shock, and inflammation than those from areas designated as less impacted by the spill.
机译：血液白细胞基因转录物谱的开发有可能将条件评估的范围扩大到目前可用于评估野生生物健康的评估范围，包括单独或作为种群的海獭Enhydra lutris。我们研究中的10个基因代表了多种生理系统，这些系统在免疫调节，炎症，细胞保护，肿瘤抑制，细胞应激反应，异种生物代谢酶和抗氧化酶中起作用。这些基因可以通过生物学，物理或人为影响进行修饰，因此可提供有关给定环境中存在的应激源一般类型的信息。我们比较了1989年威廉王子湾受1989年“埃克森·瓦尔迪兹”号溢油事件不同程度影响的海獭采样的海豚的基因转录谱，以及圈养和野生海獭的基因转录谱。与参考海獭组相比，威廉王子湾海獭的图谱显示与肿瘤形成，细胞死亡，有机物暴露，炎症和病毒暴露相关的基因转录升高，表明可能近期和长期暴露于有机污染物。漏油事件发生19年后，威廉王子湾历史上指定油区的海獭比那些受溢漏影响较小的地区的那些与肿瘤形成，细胞死亡，热休克和炎症相关的基因转录更高。

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  • 来源
    《Marine ecology progress series》 |2012年第11期|p.201-212|共12页
  • 作者

    A. K. Miles; L. Bowen; B. Ballachey; J. L. Bodkin; M. Murray; J. L. Estes; R. A. Keister; J. L. Stott;

  • 作者单位

    US Geological Survey, Western Ecological Research Center, Davis Field Station, 1 Shields Avenue,University of California, Davis, California 95616, USA;

    US Geological Survey, Western Ecological Research Center, Davis Field Station, 1 Shields Avenue,University of California, Davis, California 95616, USA;

    US Geological Survey, Alaska Science Center, 4210 University Drive, Anchorage, Alaska 99508, USA;

    US Geological Survey, Alaska Science Center, 4210 University Drive, Anchorage, Alaska 99508, USA;

    Monterey Bay Aquarium, 886 Cannery Row, Monterey, California 93940, USA;

    Department of Ecology and Evolutionary Biology, University of California, 100 Shaffer Road, Santa Cruz,California 95060, USA;

    US Geological Survey, Western Ecological Research Center, Davis Field Station, 1 Shields Avenue,University of California, Davis, California 95616, USA;

    School of Veterinary Medicine, Department of Pathology, Microbiology, and Immunology, 1 Shields Avenue,University of California, Davis, California 95616, USA;

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  • 正文语种 eng
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  • 关键词

    gene transcription; sea otter; enhydra lutris; prince william sound; exxon valdez;

    机译：基因转录海獭;黄hydr威廉王子的声音;埃克森·瓦尔迪兹;

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